AQP8 - aquaporin 8 Gene

Also Known as AQP-8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 343

About AQP8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:25,216,947-25,228,932 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 11 paralogues. Restricted expression toward colon (RPKM 257.9).

Summary

Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not Other tissues. [provided by RefSeq, Jul 2008]

AQP8 Products (1)

mRNA Protein Name
NM_001169.3 NP_001160.2 aquaporin-8

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables methylammonium channel activity IDA
IDA: Inferred from direct assay
15948717 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables water channel activity IDA
IDA: Inferred from direct assay
15948717 GOA
enables water channel activity IMP
IMP: Inferred from mutant phenotype
18948439 GOA
Biological Process GO Annotation Evidence References Source
involved in ammonium transmembrane transport IMP
IMP: Inferred from mutant phenotype
22622463 GOA
involved in cellular detoxification IMP
IMP: Inferred from mutant phenotype
34292591 GOA
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
17636236 GOA
involved in hydrogen peroxide transmembrane transport IMP
IMP: Inferred from mutant phenotype
23541115 GOA
involved in methylammonium transport IDA
IDA: Inferred from direct assay
15948717 GOA
involved in regulation of cholesterol biosynthetic process IMP
IMP: Inferred from mutant phenotype
30579780 GOA
involved in water transport IDA
IDA: Inferred from direct assay
15948717 GOA
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
12801959 GOA
located in intracellular canaliculus IDA
IDA: Inferred from direct assay
18948439 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
22622463 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AQP8 Protein Structure

MIP

MIP: Major intrinsic protein (33 - 243)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

aquaporin-8

AQP8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AQP8 O94778 SERP1 Homo sapiens Q9Y6X1
Validated Y2H
32296183
Intra
AQP8 O94778 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
AQP8 O94778 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
AQP8 O94778 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
AQP8 O94778 BAG6 Homo sapiens P46379-2
Validated Y2H
32814053
Intra
AQP8 O94778 BAG6 Homo sapiens P46379-2
Y2H Array
32814053
Intra
AQP8 O94778 BAG6 Homo sapiens P46379-2
Y2H Pooling
32814053
Intra
AQP8 O94778 PLPP6 Homo sapiens Q8IY26
Validated Y2H
32296183
Intra
AQP8 O94778 DNAJB6 Homo sapiens O75190-2
Y2H Pooling
32814053
Intra
AQP8 O94778 DNAJB6 Homo sapiens O75190-2
Validated Y2H
32814053
Intra
AQP8 O94778 DNAJB6 Homo sapiens O75190-2
Y2H Array
32814053
Intra
AQP8 O94778 CYBC1 Homo sapiens Q9BQA9
Validated Y2H
32296183
Intra
AQP8 O94778 STX12 Homo sapiens Q86Y82
Validated Y2H
32296183
Intra
AQP8 O94778 HSPB1 Homo sapiens P04792
Y2H Pooling
32814053
Intra
AQP8 O94778 HSPB1 Homo sapiens P04792
Validated Y2H
32814053
Intra
AQP8 O94778 HSPB1 Homo sapiens P04792
Y2H Array
32814053
Intra
AQP8 O94778 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
AQP8 O94778 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
AQP8 O94778 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
AQP8 O94778 PLP2 Homo sapiens Q04941
Validated Y2H
32296183
Intra
AQP8 O94778 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
AQP8 O94778 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
AQP8 O94778 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
AQP8 O94778 PRPS1 Homo sapiens P60891
Validated Y2H
32814053
Intra
AQP8 O94778 PRPS1 Homo sapiens P60891
Y2H Pooling
32814053
Intra
AQP8 O94778 PRPS1 Homo sapiens P60891
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Polyhydramnios
Palmoplantar Keratoderma, Bothnian Type

  • PPKB

  • Diffuse Palmoplantar Keratoderma, Bothnian Type

  • Bothnian Type Palmoplantar Keratoderma

  • Keratoderma, Palmoplantar, Bothnian Type

  • Palmoplantar Keratoderma, Nonepidermolytic
Crohn'S Colitis

  • Crohn Disease
Nephrogenic Diabetes Insipidus

  • Vasopressin-Resistant Diabetes Insipidus

  • Diabetes Insipidus, Nephrogenic

  • Diabetes Insipidus Nephrogenic

  • Congenital Nephrogenic Diabetes Insipidus

  • Adh Resistant Diabetes Insipidus

  • Diabetes Insipidus Nephrogenic X-Linked

  • Diabetes Insipidus Nephrogenic Type 1

  • Adh-Resistant Diabetes Insipidus

  • Diabetes Insipidus Renalis

  • Ndi

  • Renal Diabetes Insipidus

  • Familial Nephrogenic Diabetes

  • Antidiuretic-Hormone-Resistant Diabetes Insipidus

  • Adiuretin-Resistant Diabetes Insipidus

  • Ndi - [Nephrogenic Diabetes Insipidus]

  • Diabetes Tenuifluus

  • Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus

  • Hereditary Nephrogenic Diabetes Insipidus

  • Familial Nephrogenic Diabetes Insipidus

  • Primary Nephrogenic Diabetes Insipidus
Oligohydramnios

  • Oligohydramnios - Delivered

  • Antepartum Oligohydramnios

  • Delivered Oligohydramnios

  • Oligohydramnios, Antepartum Condition Or Complication

  • Deficient Liquor

  • Oligohydramnios, Unspecified Trimester

  • Reduced Liquor Volume
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00880 AQP8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris AQP8 VGNC VGNC:38020
Felis catus AQP8 VGNC VGNC:67985
Macaca mulatta AQP8 VGNC VGNC:69995
Bos taurus AQP8 VGNC VGNC:26050
Mus musculus AQP8 MGD MGI:1195271
Rattus norvegicus AQP8 RGD RGD:2146
Others AQP8 NCBI