Axl-IN-3
Axl-IN-3 is a potent, selective and orally active AXL kinase inhibitor with an IC50 of 41.5 nM. Axl-IN-3 has lower inhibition of other kinases.
For research use only. We do not sell to patients.
- CAS No.: 2783991-34-2
- Formula: C24H25ClN6O2
- Molecular Weight:464.95
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Axl |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| SK-OV-3 | GI50 |
1.02 μM
Compound: 54
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Antiproliferative activity against human SK-OV-3 cells as reduction in cell growth measured after 72 hrs by Celltiter-Glo luminescent assay
Antiproliferative activity against human SK-OV-3 cells as reduction in cell growth measured after 72 hrs by Celltiter-Glo luminescent assay
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[PMID: 34600239] |
Axl-IN-3 (Compound 54) shows anti-proliferative activity in SKOV3 cells with a GI50 of 1.02 μM[1].
Axl-IN-3 (Compound 54; 1-10 μM; pretreated 1 h) inhibits AXL signaling in SKOV3 cells. Axl-IN-3 shows a dose dependent reduction of phosphorylated AXL (pAXL) levels compared to untreated cells. Additionally, the reduction of pAXL levels also lead to the concomitant reduction in downstream pERK1/2 levels[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2783991-34-2
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Molecular Weight 464.95
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Formula C24H25ClN6O2
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SMILES
COC1=CC=C(C=C1)N2C=C(C=N2)C3=NNC4=C3C=C(C(Cl)=C4)N[C@@H]5CCN(C5)C6COC6
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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