1. Protein Tyrosine Kinase/RTK
  2. TAM Receptor
  3. Axl-IN-3

Axl-IN-3 

Cat. No.: HY-144706
Handling Instructions

Axl-IN-3 is a potent, selective and orally active AXL kinase inhibitor with an IC50 of 41.5 nM. Axl-IN-3 has lower inhibition of other kinases.

For research use only. We do not sell to patients.

Axl-IN-3 Chemical Structure

Axl-IN-3 Chemical Structure

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Description

Axl-IN-3 is a potent, selective and orally active AXL kinase inhibitor with an IC50 of 41.5 nM. Axl-IN-3 has lower inhibition of other kinases[1].

IC50 & Target

IC50: 41.5 nM (AXL kinase)[1]

In Vitro

Axl-IN-3 (Compound 54) shows anti-proliferative activity in SKOV3 cells with a GI50 of 1.02 μM[1].
Axl-IN-3 (Compound 54; 1-10 μM; pretreated 1 h) inhibits AXL signaling in SKOV3 cells. Axl-IN-3 shows a dose dependent reduction of phosphorylated AXL (pAXL) levels compared to untreated cells. Additionally, the reduction of pAXL levels also lead to the concomitant reduction in downstream pERK1/2 levels[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Pharmacokinetic studies of Axl-IN-3 (Compound 54) at 5 mg/kg reveal rapid oral absorption with a Tmax of 0.25 hr, Cmax of 460 ng/mL, T1/2 of 2.46 hr, and area under the curve (AUC) values of 1620 (ng*hr/mL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

464.95

Formula

C24H25ClN6O2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Axl-IN-3
Cat. No.:
HY-144706
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