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BI-6015 

Cat. No.: HY-108469
Handling Instructions

BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes.

For research use only. We do not sell to patients.

BI-6015 Chemical Structure

BI-6015 Chemical Structure

CAS No. : 93987-29-2

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Description

BI-6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that can inhibit the expression of known HNF4α target genes. BI6015 represses insulin promoter activity through HNF4α antagonism. BI-6015 can be used for the research of cancer and diabetes[1].

IC50 & Target

hepatocyte nuclear factor 4α (HNF4α)[1]

In Vitro

BI-6015 (1.25-20 μM; 24-72 h) is cytotoxic to human hepatocellular carcinoma (HCC)[1].
BI-6015 (2.5-10 μM; 5-48 h) inhibits HNF4α gene expression in HepG2 cells[1].
BI-6015 (5 μM; 3 d) induces hepatic steatosis in primary murine hepatocytes[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Hep3B-Luc cells and primary hepatocytes
Concentration: 1.25, 2.5, 5, 10, 20 μM
Incubation Time: 24, 48, 72 hours
Result: Was markedly toxic to Hep3B cells but spared primary hepatocytes.
In Vivo

BI-6015 (10-30 mg/kg; i.p. once daily for 5 days) induces loss of HNF4α expression and hepatic steatosis in mice[1].
BI-6015 (10-30 mg/kg; i.p. daily or every other day for 20-57 days) induces apoptosis in a human hepatocellular carcinoma mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

331.35

Formula

C₁₅H₁₃N₃O₄S

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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BI-6015
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HY-108469
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