E-4441
E-4441 is an orally active Antibacterial agent. E-4441 exerts broad-spectrum in vitro antibacterial activity against Gram-positive bacteria and aerobic bacteria. E-4441 exhibits protective effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections. E-4441 can be used in the research of systemic bacterial infections (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections).
For research use only. We do not sell to patients.
- CAS No.: 124668-12-8
- Formula: C17H17F2N3O3
- Molecular Weight:349.34
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
E-4441 (4 μg/mL) inhibits all anaerobic bacteria[1].
For 90% of Gram-positive bacterial isolates (Staphylococcus, Streptococcus, and Enterococcus faecalis), the minimum inhibitory concentration (MIC) of E-4441 (18 h) ranges from 0.12 to 1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Escherichia coli HM-42 infection in mice, with an ED50 of 3.0 mg/kg following a single oral dose, identical to the ED50 of ciprofloxacin[1].
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Pseudomonas aeruginosa HS-116 infection in mice, with an ED50 of 71.7 mg/kg following a single oral dose, efficacy comparable to Ciprofloxacin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Staphylococcus aureus HS-93)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 14.7 mg/kg.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Escherichia coli HM-42)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 3.0 mg/kg, matching the ED50 of ciprofloxacin.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Pseudomonas aeruginosa HS-116)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 71.7 mg/kg, efficacy comparable to ciprofloxacin.
Chemical Information
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CAS No. 124668-12-8
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Molecular Weight 349.34
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Formula C17H17F2N3O3
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SMILES
O=C(O)C1=CN(C2=C(F)C(=C(F)C=C2C1=O)N3CC(N)(C)C3)C4CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E-4441 Related Classifications
HY-116558 Related Classifications
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