WIF1 - WNT inhibitory factor 1 Gene

Also Known as WIF-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 11197

About WIF1

Cytogenetic location: 12q14.3 Genomic coordinates (GRCh38): 12:65,050,626-65,121,305 (from NCBI)

This gene has 3 transcripts (splice variants), 169 orthologues, 8 paralogues and is associated with 60 phenotypes. Biased expression in lung (RPKM 69.2), brain (RPKM 9.8) and 3 other tissues.

Summary

The protein encoded by this gene functions to inhibit Wnt proteins, which are extracellular signaling molecules that play a role in embryonic development. This protein contains a Wnt inhibitory factor (WIF) domain and five epidermal growth factor (EGF)-like domains, and is thought to be involved in mesoderm segmentation. This gene functions as a tumor suppressor gene, and has been found to be epigenetically silenced in various cancers. [provided by RefSeq, Jun 2010]

WIF1 Products (1)

mRNA Protein Name
NM_007191.5 NP_009122.2 wnt inhibitory factor 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
19188438 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WIF1 Protein Structure

WIF

WIF: WIF domain (38 - 173)

hEGF

hEGF: Human growth factor-like EGF (198 - 209)

hEGF

hEGF: Human growth factor-like EGF (230 - 241)

hEGF

hEGF: Human growth factor-like EGF (261 - 273)

hEGF

hEGF: Human growth factor-like EGF (325 - 337)

  • 0
  • 100
  • 200
  • 300
  • 379 a.a.
Protein Preferred Names Protein Names

wnt inhibitory factor 1

WIF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WIF1 Q9Y5W5 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
WIF1 Q9Y5W5 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
WIF1 Q9Y5W5 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
WIF1 Q9Y5W5 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Cross
WIF1 Q9Y5W5 Wnt5a Mus musculus P22725
SPR
22986341
Cross
WIF1 Q9Y5W5 Wnt5a Mus musculus P22725
Competition Binding
22986341
Cross
WIF1 Q9Y5W5 Wnt3a Mus musculus P27467
Competition Binding
22986341
Cross
WIF1 Q9Y5W5 Wnt3a Mus musculus P27467
SPR
22986341
Cross
WIF1 Q9Y5W5 Wnt3a Mus musculus P27467
SPR
21743455
Intra
WIF1 Q9Y5W5 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
WIF1 Q9Y5W5 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
WIF1 Q9Y5W5 WNT5A Homo sapiens P41221
SPR
26342861
Intra
WIF1 Q9Y5W5 WNT7A Homo sapiens O00755
SPR
22986341
Intra
WIF1 Q9Y5W5 WNT7A Homo sapiens O00755
SPR
26342861
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant WIF1 Proteins

Cat. No. Product Name Accession Purity
HY-P70982 WIF-1 Protein, Human (HEK293, His) AAH18037.1 (G29-W379) ≥ 95%, as determined by reducing SDS-PAGE.

WIF1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82919 WIF1 Antibody (YA2664) WB, IP Human, Mouse, Rat
HY-P83228 Wnt2 Antibody (YA2973) WB Human, Mouse, Rat
HY-P84898 WIF1 Antibody (YA4595) WB, IHC-P, ICC/IF, ELISA Human
HY-P84898A WIF1 Antibody (YA4595)(PBS only) WB, IHC-P, ICC/IF, ELISA Human

Related Diseases

Diseases Alias
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Squamous Cell Papilloma

  • Papilloma

  • Epidermoid Papilloma

  • Papilloma, Squamous Cell
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Spinocerebellar Ataxia 44

  • SCA44
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15816 WIF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18157 Wif1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24631 Wif1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris WIF1 VGNC VGNC:48409
Felis catus WIF1 VGNC VGNC:67072
Mus musculus WIF1 MGD MGI:1344332
Bos taurus WIF1 VGNC VGNC:36938
Rattus norvegicus WIF1 RGD RGD:619774
Macaca mulatta WIF1 VGNC VGNC:79110
Others WIF1 NCBI