WNT5A - Wnt family member 5A Gene

Also Known as hWNT5A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7474

About WNT5A

Cytogenetic location: 3p14.3 Genomic coordinates (GRCh38): 3:55,465,715-55,505,263 (from NCBI)

This gene has 7 transcripts (splice variants), 214 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in urinary bladder (RPKM 9.1), endometrium (RPKM 7.3) and 19 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the Wnt family that signals through both the canonical and non-canonical Wnt pathways. This protein is a ligand for the seven transmembrane receptor Frizzled-5 and the tyrosine kinase Orphan Receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]

WNT5A Products (4)

mRNA	Protein	Name
NM_001256105.1	NP_001243034.1	protein Wnt-5a isoform 2 precursor
NM_001377271.1	NP_001364200.1	protein Wnt-5a isoform 2 precursor
NM_001377272.1	NP_001364201.1	protein Wnt-5a isoform 2 precursor
NM_003392.7	NP_003383.4	protein Wnt-5a isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	18174455	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22784633	GOA
enables receptor tyrosine kinase-like orphan receptor binding	IPI IPI: Inferred from physical interaction	18287027	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt signaling pathway	IDA IDA: Inferred from direct assay	20034610	GOA
involved in Wnt signaling pathway, calcium modulating pathway	IMP IMP: Inferred from mutant phenotype	17986384	GOA
acts upstream of activation of protein kinase B activity	IDA IDA: Inferred from direct assay	20034610	GOA
involved in cellular response to calcium ion	IEP IEP: Inferred from expression pattern	18703641	GOA
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18174455	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	15040835	GOA
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	18174455	GOA
involved in embryonic skeletal system development	IMP IMP: Inferred from mutant phenotype	19918918	GOA
involved in epithelial to mesenchymal transition	IEP IEP: Inferred from expression pattern	12841867	GOA
involved in face development	IMP IMP: Inferred from mutant phenotype	19918918	GOA
involved in genitalia development	IMP IMP: Inferred from mutant phenotype	19918918	GOA
involved in hematopoietic stem cell proliferation	IDA IDA: Inferred from direct assay	9787155	GOA
involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	31512787	GOA
involved in keratinocyte differentiation	IEP IEP: Inferred from expression pattern	19399181	GOA
involved in macrophage derived foam cell differentiation	IMP IMP: Inferred from mutant phenotype	31512787	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	17848411	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	19277043	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	19251946	GOA
acts upstream of or within negative regulation of canonical Wnt signaling pathway	IGI IGI: Inferred from genetic interaction	12952940	GOA
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	20032469	GOA
involved in negative regulation of mesenchymal cell proliferation	IDA IDA: Inferred from direct assay	19878652	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	19099253	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19847889	GOA
acts upstream of positive regulation of JUN kinase activity	IDA IDA: Inferred from direct assay	20034610	GOA
involved in positive regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	20032469	GOA
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	18287027	GOA
involved in positive regulation of T cell chemotaxis	IMP IMP: Inferred from mutant phenotype	19520808	GOA
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	17035633	GOA
involved in positive regulation of chemokine production	IMP IMP: Inferred from mutant phenotype	19520808	GOA
involved in positive regulation of cytokine production involved in immune response	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17035633	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	17986384	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	19251946	GOA
involved in positive regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of macrophage activation	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of ossification	IMP IMP: Inferred from mutant phenotype	20032469	GOA
acts upstream of or within positive regulation of protein catabolic process	IGI IGI: Inferred from genetic interaction	12952940	GOA
involved in positive regulation of protein kinase C activity	IMP IMP: Inferred from mutant phenotype	12086864	GOA
involved in positive regulation of response to cytokine stimulus	IDA IDA: Inferred from direct assay	19399181	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	18174455	GOA
involved in positive regulation of type I interferon-mediated signaling pathway	IDA IDA: Inferred from direct assay	19399181	GOA
involved in protein localization	IDA IDA: Inferred from direct assay	19177143	GOA
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	27402827	GOA
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	27402827	GOA
involved in regulation of postsynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	27402827	GOA
involved in regulation of postsynaptic cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	27402827	GOA
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	18986540	GOA
involved in regulation of synapse organization	IMP IMP: Inferred from mutant phenotype	18986540	GOA
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	18413325	GOA
involved in wound healing	IDA IDA: Inferred from direct assay	19878652	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18703641	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	18986540	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	18986540	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT5A Protein Structure

wnt

0
100
200
300
380 a.a.

Protein Preferred Names	Protein Names
protein Wnt-5a	WNT-5A protein

WNT5A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WNT5A	P41221	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	33961781
Intra	WNT5A	P41221	WLS	Homo sapiens	Q5T9L3	Anti Tag CoIP	22784633
Intra	WNT5A	P41221	WIF1	Homo sapiens	Q9Y5W5	SPR	26342861

Cross: Cross-species interaction Intra: Intraspecies interaction

WNT5A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80933	Wnt5a Antibody (YA007)	WB, ICC/IF	Human
HY-P80933A	Wnt5a Antibody (YA007)(PBS only)	WB, ICC/IF	Human
HY-P84305	Wnt5a Antibody (YA4002)	IHC-P, ICC/IF, ELISA	Human
HY-P84305A	Wnt5a Antibody (YA4002)(PBS only)	IHC-P, ICC/IF, ELISA	Human
HY-P85411	Wnt5a Antibody (YA5103)	WB; ICC/IF; FC	Human

Related Diseases

Diseases	Alias
Robinow Syndrome, Autosomal Dominant 1	Autosomal Dominant Robinow Syndrome 1 DRS1 Robinow Dwarfism Fetal Face Syndrome Acral Dysostosis With Facial And Genital Abnormalities Robinow, Autosomal Dominant Syndrome, Type 1
Autosomal Dominant Robinow Syndrome	Fetal Face Syndrome Robinow Syndrome, Autosomal Dominant
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Brachydactyly, Type B1	Brachydactyly Type B1 Brachydactyly Type B BDB1 Brachydactyly, Type B Bdb Brachydactyly B1
Achondroplasia	Achondroplastic Dwarfism ACH Osteosclerosis Congenita Achondroplastic Physique Chondrodystrophia Dwarf, Achondroplastic Achondroplastic Short Stature Congenital Osteosclerosis
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Omodysplasia	Omodysplasia Type 1 Omodysplasia 2
Gallbladder Melanoma	Malignant Melanoma Of Gallbladder
Focal Dermal Hypoplasia	Goltz Syndrome Goltz-Gorlin Syndrome FDH FODH Dhof Goltz Gorlin Syndrome Hypoplasia, Dermal, Focal
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Medulloblastoma	MDB Cpnet Localized Primitive Neuroectodermal Tumor Classic Medulloblastoma Medulloblastoma Predisposition Syndrome Medulloblastoma, Somatic Brain Medulloblastoma Cns Pnet Infratentorial Primitive Neuroectodermal Tumor Neuroectodermal Tumors, Primitive Medulloblastomas Desmoplastic Medulloblastoma Medulloblastoma, With Extensive Nodularity Medulloblastoma Of Unspecified Site Medullomyoblastoma Of Unspecified Site
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Fallopian Tube Serous Adenocarcinoma
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Orofacial Cleft	Cleft, Orofacial
Brachydactyly
Osteochondrodysplasia	Skeletal Dysplasia Chondrodystrophy Congenital Anomaly Of Cartilage Osteochondrodysplasias Cartilage Development Disorder Osteochondrodysplasia Syndrome Dysplasia, Skeletal Mucopolysaccharidosis Iv
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1416A	Foxy-5 TFA	Agonist	99.17%	Phase 2

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99201	Zilovertamab	Inhibitor	98.21%	Phase 3

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-123071	Box5	Antagonist	98.81%	Unkown
HY-P1416	Foxy-5	Agonist	99.02%	Unkown
HY-123071A	Box5 TFA	Antagonist	99.50%	Unkown
HY-12557	γ-Glutamylvaline		99.94%	Unkown
HY-116553	FzM1	Inhibitor	98.72%	Unkown
HY-RS15837	WNT5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11867	UM206_L	Activator	/	Unkown
HY-P11867A	UM206_C	Activator	/	Unkown
HY-N0836A	Jervine hydriodide		/	Unkown
HY-P5171	MDGCEL	Antagonist	/	Unkown
HY-RS17616	Wnt5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24076	Wnt5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	WNT5A	VGNC	VGNC:36960
Macaca mulatta	WNT5A	VGNC	VGNC:110318
Rattus norvegicus	WNT5A	RGD	RGD:69250
Mus musculus	WNT5A	MGD	MGI:98958
Felis catus	WNT5A	VGNC	VGNC:102731
Canis familiaris	WNT5A	VGNC	VGNC:48425
Others	WNT5A	NCBI