PEX26 - peroxisomal biogenesis factor 26 Gene
Also Known as PBD7A; PBD7B; PEX26M1T; Pex26pM1T
Species: Homo sapiens
About PEX26
This gene has 3 transcripts (splice variants), 179 orthologues and is associated with 7 phenotypes. Ubiquitous expression in colon (RPKM 17.4), small intestine (RPKM 11.2) and 25 other tissues.
Summary
This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]
PEX26 Products (3)
| mRNA | Protein | Name |
|---|---|---|
| NM_001127649.3 | NP_001121121.1 | peroxisome assembly protein 26 isoform a |
| NM_001199319.2 | NP_001186248.1 | peroxisome assembly protein 26 isoform b |
| NM_017929.6 | NP_060399.1 | peroxisome assembly protein 26 isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables ATPase binding |
IPI
IPI: Inferred from physical interaction
|
16257970 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
15713480 | GOA |
| enables protein-containing complex binding |
IDA
IDA: Inferred from direct assay
|
16854980 | GOA |
| enables protein-membrane adaptor activity |
IDA
IDA: Inferred from direct assay
|
12717447 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in protein import into peroxisome matrix |
IDA
IDA: Inferred from direct assay
|
12717447 | GOA |
| involved in protein import into peroxisome matrix |
IMP
IMP: Inferred from mutant phenotype
|
15858711 | GOA |
| involved in protein to membrane docking |
IDA
IDA: Inferred from direct assay
|
12717447 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in peroxisomal membrane |
IDA
IDA: Inferred from direct assay
|
12717447 | GOA |
| located in peroxisome |
IDA
IDA: Inferred from direct assay
|
15858711 | GOA |
PEX26 Protein Structure
Pex26: Pex26 protein (1 - 305)
- 0
- 100
- 200
- 305 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
peroxisome assembly protein 26 |
|
PEX26 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PEX26 | Q7Z412 | ARL16 | Homo sapiens | Q0P5N6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ARL16 | Homo sapiens | Q0P5N6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ARL16 | Homo sapiens | Q0P5N6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | FOXR1 | Homo sapiens | Q6PIV2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | FOXR1 | Homo sapiens | Q6PIV2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | FOXR1 | Homo sapiens | Q6PIV2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ASCL4 | Homo sapiens | Q6XD76 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ASCL4 | Homo sapiens | Q6XD76 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ASCL4 | Homo sapiens | Q6XD76 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KRTAP8-1 | Homo sapiens | Q8IUC2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KRTAP8-1 | Homo sapiens | Q8IUC2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KRTAP8-1 | Homo sapiens | Q8IUC2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | AP2B1 | Homo sapiens | P63010-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | AP2B1 | Homo sapiens | P63010-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | AP2B1 | Homo sapiens | P63010-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KCTD15 | Homo sapiens | Q96SI1-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KCTD15 | Homo sapiens | Q96SI1-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KCTD15 | Homo sapiens | Q96SI1-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KRTAP19-1 | Homo sapiens | Q8IUB9 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SASS6 | Homo sapiens | Q6UVJ0 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SASS6 | Homo sapiens | Q6UVJ0 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SASS6 | Homo sapiens | Q6UVJ0 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KLC3 | Homo sapiens | Q6P597 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KLC3 | Homo sapiens | Q6P597 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | KLC3 | Homo sapiens | Q6P597 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MKL1 | Homo sapiens | A4FUJ8 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MKL1 | Homo sapiens | A4FUJ8 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MKL1 | Homo sapiens | A4FUJ8 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | IQSEC1 | Homo sapiens | Q6DN90-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | IQSEC1 | Homo sapiens | Q6DN90-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | IQSEC1 | Homo sapiens | Q6DN90-2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ABHD17C | Homo sapiens | Q6PCB6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ABHD17C | Homo sapiens | Q6PCB6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ABHD17C | Homo sapiens | Q6PCB6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MKRN3 | Homo sapiens | Q13064 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MKRN3 | Homo sapiens | Q13064 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MKRN3 | Homo sapiens | Q13064 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | RNF112 | Homo sapiens | Q9ULX5 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | RNF112 | Homo sapiens | Q9ULX5 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | RNF112 | Homo sapiens | Q9ULX5 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | LOC642947 | Homo sapiens | Q6ZP95 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | LOC642947 | Homo sapiens | Q6ZP95 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | LOC642947 | Homo sapiens | Q6ZP95 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | LHX5 | Homo sapiens | Q9H2C1 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | LHX5 | Homo sapiens | Q9H2C1 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | LHX5 | Homo sapiens | Q9H2C1 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ZMAT2 | Homo sapiens | Q96NC0 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ZMAT2 | Homo sapiens | Q96NC0 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ZMAT2 | Homo sapiens | Q96NC0 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MEOX1 | Homo sapiens | P50221 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MEOX1 | Homo sapiens | P50221 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MEOX1 | Homo sapiens | P50221 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | NEBL | Homo sapiens | O76041 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | NEBL | Homo sapiens | O76041 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | NEBL | Homo sapiens | O76041 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | HDAC10 | Homo sapiens | Q969S8 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | HDAC10 | Homo sapiens | Q969S8 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | HDAC10 | Homo sapiens | Q969S8 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | COPS3 | Homo sapiens | Q9UNS2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | COPS3 | Homo sapiens | Q9UNS2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | COPS3 | Homo sapiens | Q9UNS2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | PFDN5 | Homo sapiens | Q99471 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | PFDN5 | Homo sapiens | Q99471 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | PFDN5 | Homo sapiens | Q99471 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SKIC8 | Homo sapiens | Q9GZS3 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SKIC8 | Homo sapiens | Q9GZS3 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SKIC8 | Homo sapiens | Q9GZS3 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | TP53 | Homo sapiens | P04637 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | TP53 | Homo sapiens | P04637 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | TP53 | Homo sapiens | P04637 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BMF | Homo sapiens | Q96LC9 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BMF | Homo sapiens | Q96LC9 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BMF | Homo sapiens | Q96LC9 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BIRC5 | Homo sapiens | O15392 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BIRC5 | Homo sapiens | O15392 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BIRC5 | Homo sapiens | O15392 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | PEX19 | Homo sapiens | P40855 | 32296183 | |
|
Intra
|
PEX26 | Q7Z412 | PEX19 | Homo sapiens | P40855 | 32296183 | |
|
Intra
|
PEX26 | Q7Z412 | ZNG1C | Homo sapiens | Q5JTY5 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ZNG1C | Homo sapiens | Q5JTY5 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | ZNG1C | Homo sapiens | Q5JTY5 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | SUFU | Homo sapiens | Q9UMX1 | 16189514 | |
|
Intra
|
PEX26 | Q7Z412 | BBLN | Homo sapiens | Q9BUW7 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BBLN | Homo sapiens | Q9BUW7 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | BBLN | Homo sapiens | Q9BUW7 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | DAXX | Homo sapiens | Q9UER7 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | DAXX | Homo sapiens | Q9UER7 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | DAXX | Homo sapiens | Q9UER7 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | E2F8 | Homo sapiens | A0AVK6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | E2F8 | Homo sapiens | A0AVK6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | E2F8 | Homo sapiens | A0AVK6 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | q7z783_human | Homo sapiens | Q7Z783 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | q7z783_human | Homo sapiens | Q7Z783 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | q7z783_human | Homo sapiens | Q7Z783 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MSRB2 | Homo sapiens | Q9Y3D2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MSRB2 | Homo sapiens | Q9Y3D2 | 32814053 | |
|
Intra
|
PEX26 | Q7Z412 | MSRB2 | Homo sapiens | Q9Y3D2 | 32814053 |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Peroxisome Biogenesis Disorder 7a |
|
|
| Peroxisome Biogenesis Disorder 7b |
|
|
| Peroxisome Biogenesis Disorder 1b |
|
|
| Neonatal Adrenoleukodystrophy |
|
|
| Zellweger Spectrum Disorder |
|
|
| Zellweger Syndrome |
|
|
| Rhizomelic Chondrodysplasia Punctata |
|
|
| Adrenoleukodystrophy |
|
|
| Peroxisomal Biogenesis Disorder |
|
|
| Deafness, Autosomal Recessive 59 |
|
|
| Refsum Disease, Classic |
|
|
| Linear Skin Defects With Multiple Congenital Anomalies 1 |
|
|
| Peroxisomal Disease |
|
|
| Deafness, Autosomal Dominant 59 |
|
|
| Chondrodysplasia Punctata Syndrome |
|
|
| Chromosome 17q12 Deletion Syndrome |
|
|
| Albinism, Ocular, With Late-Onset Sensorineural Deafness |
|
|
| Alpha-Methylacyl-Coa Racemase Deficiency |
|
|
| Fraser Syndrome 1 |
|
|
| Sensorineural Hearing Loss |
|
|
| Cornelia De Lange Syndrome 1 |
|
|
| Cerebral Degeneration |
|
|
| Leukodystrophy |
|
|
| Fundus Dystrophy |
|
|
| Retinitis Pigmentosa |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | PEX26 | RGD | RGD:1584998 |
| Felis catus | PEX26 | VGNC | VGNC:64115 |
| Bos taurus | PEX26 | VGNC | VGNC:32759 |
| Mus musculus | PEX26 | MGD | MGI:1921293 |
| Canis familiaris | PEX26 | VGNC | VGNC:44433 |
| Macaca mulatta | PEX26 | VGNC | VGNC:97122 |
| Others | PEX26 | NCBI |