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FOXR1 - forkhead box R1 Gene

Also Known as FOXN5; DLNB13

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283150

About FOXR1

Cytogenetic location: 11q23.3 Genomic coordinates (GRCh38): 11:118,971,761-118,981,287 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 82 orthologues, 42 paralogues and is associated with 42 phenotypes. Restricted expression toward testis (RPKM 1.2).

Summary

This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many Other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

FOXR1 Products (1)

mRNA	Protein	Name
NM_181721.3	NP_859072.1	forkhead box protein R1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	34723967	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	34723967	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	34723967	GOA
involved in regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	34723967	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	34723967	GOA
located in nucleus	IDA IDA: Inferred from direct assay	34723967	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXR1 Protein Structure

Forkhead

0
100
200
292 a.a.

Protein Preferred Names	Protein Names
forkhead box protein R1	forkhead box protein N5

FOXR1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	FOXR1	Q6PIV2	FLJ13057	Homo sapiens	Q53SE7	Validated Y2H	25416956
Intra	FOXR1	Q6PIV2	FLJ13057	Homo sapiens	Q53SE7	Y2H Prey Pooling	25416956
Intra	FOXR1	Q6PIV2	FLJ13057	Homo sapiens	Q53SE7	Y2H Array	25416956
Intra	FOXR1	Q6PIV2	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	FOXR1	Q6PIV2	BANP	Homo sapiens	Q8N9N5-2	Y2H Array	32296183
Intra	FOXR1	Q6PIV2	BANP	Homo sapiens	Q8N9N5-2	Y2H Prey Pooling	32296183
Intra	FOXR1	Q6PIV2	MECP2	Homo sapiens	P51608	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	MECP2	Homo sapiens	P51608	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	MECP2	Homo sapiens	P51608	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	FOXR1	Q6PIV2	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	FOXR1	Q6PIV2	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	FOXR1	Q6PIV2	TOR1A	Homo sapiens	O14656-2	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	TOR1A	Homo sapiens	O14656-2	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	TOR1A	Homo sapiens	O14656-2	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	SMN1	Homo sapiens	Q16637	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	SMN1	Homo sapiens	Q16637	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	SMN1	Homo sapiens	Q16637	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	A2M	Homo sapiens	P01023	Validated Y2H	32814053
Intra	FOXR1	Q6PIV2	A2M	Homo sapiens	P01023	Y2H Array	32814053
Intra	FOXR1	Q6PIV2	A2M	Homo sapiens	P01023	Y2H Pooling	32814053
Intra	FOXR1	Q6PIV2	DPPA4	Homo sapiens	Q7L190	Y2H Prey Pooling	32296183
Intra	FOXR1	Q6PIV2	DPPA4	Homo sapiens	Q7L190	Validated Y2H	32296183
Intra	FOXR1	Q6PIV2	DPPA4	Homo sapiens	Q7L190	Y2H Array	32296183
Intra	FOXR1	Q6PIV2	PPCDC	Homo sapiens	Q96CD2	Validated Y2H	32296183
Intra	FOXR1	Q6PIV2	PPCDC	Homo sapiens	Q96CD2	Y2H Prey Pooling	32296183
Intra	FOXR1	Q6PIV2	PPCDC	Homo sapiens	Q96CD2	Y2H Array	25416956
Intra	FOXR1	Q6PIV2	PPCDC	Homo sapiens	Q96CD2	Y2H Array	32296183
Intra	FOXR1	Q6PIV2	CEP19	Homo sapiens	Q96LK0	Validated Y2H	32296183
Intra	FOXR1	Q6PIV2	BANP	Homo sapiens	Q8N9N5	Y2H Prey Pooling	25416956
Intra	FOXR1	Q6PIV2	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	FOXR1	Q6PIV2	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	FOXR1	Q6PIV2	MEOX2	Homo sapiens	P50222	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cns Neuroblastoma With Foxr2 Activation	Central Nervous System Neuroblastoma With Foxr2 Activation Cns Nb-Foxr2 Cns Neuroblastoma, Foxr2-Activated
Central Nervous System Neuroblastoma
Central Nervous System Germ Cell Tumor	Central Nervous System Germ Cell Tumour Germ Cell Tumor Of The Cns Germ Cell Tumour Of The Cns
Lymphedema-Distichiasis Syndrome	Lymphedema With Distichiasis Lymphedema-Distichiasis Syndrome With Renal Disease And Diabetes Mellitus LPHDST Distichiasis-Lymphedema Syndrome Lymphedema Distichiasis Syndrome Hereditary Lymphedema-Distichiasis Syndrome Lymphedema Distichiasis
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05078	FOXR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	FOXR1	VGNC	VGNC:40969
Rattus norvegicus	FOXR1	RGD	RGD:1309739
Macaca mulatta	FOXR1	VGNC	VGNC:107449
Bos taurus	FOXR1	VGNC	VGNC:29104
Felis catus	FOXR1	VGNC	VGNC:62347
Mus musculus	FOXR1	MGD	MGI:2685961
Others	FOXR1	NCBI