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ARL16 - ADP ribosylation factor like GTPase 16 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 339231

About ARL16

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,681,165-81,683,797 (from NCBI)

This gene has 13 transcripts (splice variants), 147 orthologues and 30 paralogues. Ubiquitous expression in kidney (RPKM 11.1), thyroid (RPKM 10.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). This protein has been shown to have an inhibitory role in the cellular Antiviral response. This gene product interacts with the C-terminal domain of the DEXD/H-box helicase 58 (DDX58) gene product. This interaction was found to suppress the association between the DDX58 gene product and RNA, thereby negatively regulating the activity of the DDX58 gene product. [provided by RefSeq, Jul 2016]

ARL16 Products (3)

mRNA	Protein	Name
NM_001040025.3	NP_001035114.2	ADP-ribosylation factor-like protein 16 isoform 1
NM_001329608.2	NP_001316537.1	ADP-ribosylation factor-like protein 16 isoform 2
NM_001329609.2	NP_001316538.1	ADP-ribosylation factor-like protein 16 isoform 3

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21233210	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21233210	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARL16 Protein Structure

Arf

0
100
197 a.a.

Protein Preferred Names	Protein Names
ADP-ribosylation factor-like protein 16

ARL16 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARL16	Q0P5N6	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	ARL16	Q0P5N6	TCF12	Homo sapiens	Q99081-3	Validated Y2H	32296183
Intra	ARL16	Q0P5N6	TCF12	Homo sapiens	Q99081-3	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	TCF12	Homo sapiens	Q99081-3	Y2H Array	32296183
Intra	ARL16	Q0P5N6	GLYR1	Homo sapiens	Q49A26-4	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	GLYR1	Homo sapiens	Q49A26-4	Validated Y2H	32296183
Intra	ARL16	Q0P5N6	GLYR1	Homo sapiens	Q49A26-4	Y2H Array	32296183
Intra	ARL16	Q0P5N6	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	ARL16	Q0P5N6	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	APP	Homo sapiens	P05067-2	Y2H Pooling	32814053
Intra	ARL16	Q0P5N6	APP	Homo sapiens	P05067-2	Validated Y2H	32814053
Intra	ARL16	Q0P5N6	APP	Homo sapiens	P05067-2	Y2H Array	32814053
Intra	ARL16	Q0P5N6	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
Intra	ARL16	Q0P5N6	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
Intra	ARL16	Q0P5N6	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
Intra	ARL16	Q0P5N6	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	ARL16	Q0P5N6	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	ARL16	Q0P5N6	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	ARL16	Q0P5N6	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
Intra	ARL16	Q0P5N6	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
Intra	ARL16	Q0P5N6	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
Intra	ARL16	Q0P5N6	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	GOLGA2	Homo sapiens	Q08379	Y2H Array	25416956
Intra	ARL16	Q0P5N6	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	ARL16	Q0P5N6	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	25416956
Intra	ARL16	Q0P5N6	AMPH	Homo sapiens	P49418	Y2H Array	31515488
Intra	ARL16	Q0P5N6	AMPH	Homo sapiens	P49418	Y2H Prey Pooling	25416956
Intra	ARL16	Q0P5N6	AMPH	Homo sapiens	P49418	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	AMPH	Homo sapiens	P49418	Y2H Array	32296183
Intra	ARL16	Q0P5N6	PDE6D	Homo sapiens	O43924	Y2H Prey Pooling	25416956
Intra	ARL16	Q0P5N6	PDE6D	Homo sapiens	O43924	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	PDE6D	Homo sapiens	O43924	Y2H Array	25416956
Intra	ARL16	Q0P5N6	PDE6D	Homo sapiens	O43924	Y2H Array	32296183
Intra	ARL16	Q0P5N6	PDE6D	Homo sapiens	O43924	MAPPIT	32296183
Intra	ARL16	Q0P5N6	DEUP1	Homo sapiens	Q05D60	Y2H Array	32296183
Intra	ARL16	Q0P5N6	DEUP1	Homo sapiens	Q05D60	Y2H Prey Pooling	32296183
Intra	ARL16	Q0P5N6	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
Intra	ARL16	Q0P5N6	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053
Intra	ARL16	Q0P5N6	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Childhood-Onset Schizophrenia	Childhood Schizophrenia Schizophrenia, Childhood
Accommodative Esotropia	Esotropia With Accommodative Compensation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00984	ARL16 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARL16	VGNC	VGNC:99118
Bos taurus	ARL16	VGNC	VGNC:26141
Mus musculus	ARL16	MGD	MGI:1917567
Rattus norvegicus	ARL16	RGD	RGD:1590059
Felis catus	ARL16	VGNC	VGNC:59924
Canis familiaris	ARL16	VGNC	VGNC:38109
Others	ARL16	NCBI