MSRB2 - methionine sulfoxide reductase B2 Gene

Also Known as CBS1; MSRB; PILB; CBS-1; CGI-131

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22921

About MSRB2

Cytogenetic location: 10p12.2 Genomic coordinates (GRCh38): 10:23,095,579-23,122,013 (from NCBI)

This gene has 3 transcripts (splice variants), 101 orthologues and 3 paralogues. Ubiquitous expression in heart (RPKM 17.2), liver (RPKM 8.9) and 24 other tissues.

Summary

Predicted to enable actin binding activity; peptide-methionine (R)-S-oxide reductase activity; and zinc ion binding activity. Predicted to be involved in actin filament polymerization and protein repair. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MSRB2 Products (1)

mRNA Protein Name
NM_012228.4 NP_036360.3 methionine-R-sulfoxide reductase B2, mitochondrial precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27499296 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSRB2 Protein Structure

SelR

SelR: SelR domain (52 - 179)

  • 0
  • 100
  • 182 a.a.
Protein Preferred Names Protein Names

methionine-R-sulfoxide reductase B2, mitochondrial

  • pilin-like transcription factor

MSRB2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MSRB2 Q9Y3D2 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
MSRB2 Q9Y3D2 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 APOE Homo sapiens P02649
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 APOE Homo sapiens P02649
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 APOE Homo sapiens P02649
Y2H Pooling
32814053
Intra
MSRB2 Q9Y3D2 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
MSRB2 Q9Y3D2 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 TRAF2 Homo sapiens Q12933
Y2H Prey Pooling
32296183
Intra
MSRB2 Q9Y3D2 TRAF2 Homo sapiens Q12933
Y2H Array
32296183
Intra
MSRB2 Q9Y3D2 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
MSRB2 Q9Y3D2 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
Intra
MSRB2 Q9Y3D2 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 NDRG1 Homo sapiens Q92597
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 NDRG1 Homo sapiens Q92597
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 NDRG1 Homo sapiens Q92597
Y2H Pooling
32814053
Intra
MSRB2 Q9Y3D2 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
MSRB2 Q9Y3D2 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
MSRB2 Q9Y3D2 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hypomagnesemia 6, Renal

  • Renal Hypomagnesemia 6

  • HOMG6

  • Renal Hypomagnesemia-6

  • Hypomagnesemia 6

  • Hypomagnesemia, Type 6, Renal
Neu-Laxova Syndrome 2

  • NLS2
Myotonia Congenita

  • Congenital Myotonia, Autosomal Dominant Form

  • Congenital Myotonia

  • Thomsen And Becker Disease

  • Thomsen Disease

  • Thomsen'S Disease

  • Generalized Myotonia Of Thomsen

  • Congenital Myotonic Muscular Dystrophy

  • Myotonia Congenita Nos
Atrial Septal Defect 1

  • ASD1

  • Atrial Heart Septal Defect 1

  • Asd
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08727 MSRB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19718 Msrb3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MSRB2 VGNC VGNC:74786
Bos taurus MSRB2 VGNC VGNC:31706
Rattus norvegicus MSRB2 RGD RGD:1306026
Mus musculus MSRB2 MGD MGI:1923717
Canis familiaris MSRB2 VGNC VGNC:43450
Others MSRB2 NCBI