HDAC10 - histone deacetylase 10 Gene

Homo sapiens

Also known as HD10

Gene ID: 83933 | Gene type: protein coding

About HDAC10

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,245,183-50,251,265 (from NCBI)

This gene has 22 transcripts (splice variants), 181 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

HDAC10 Products(2)

mRNA	Protein	Name
NM_001159286.2	NP_001152758.1	polyamine deacetylase HDAC10 isoform 2
NM_032019.6	NP_114408.3	polyamine deacetylase HDAC10 isoform 1

HDAC10 Protein Structure

Hist_deacetyl

0
200
400
600
669 a.a.

Protein Preferred Names

Protein Names

polyamine deacetylase HDAC10

Related Diseases

Diseases

Alias

Conjugate Gaze Palsy

Palsy Of Conjugate Gaze	Supranuclear Ocular Palsy
Gaze Palsy

Spinocerebellar Ataxia, X-Linked 5

SCAX5	X-Linked Spinocerebellar Ataxia 5
X-Linked Non Progressive Cerebellar Ataxia

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-109015	Tucidinostat	Inhibitor	98.70%	Unkown
HY-13322	Pracinostat	Inhibitor	99.82%	Yes
HY-B0494	Bufexamac	Inhibitor	≥98.0%	Unkown

Clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Phase
HY-10990	Abexinostat	Inhibitor	98.61%	Phase 3
HY-14842B	Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%	Phase 3
HY-14842	Givinostat	Inhibitor	98.05%	Phase 3
HY-14842A	Givinostat hydrochloride	Inhibitor	/	Phase 3
HY-15433	Quisinostat	Inhibitor	98.34%	Phase 2
HY-13522	Fimepinostat	Inhibitor	99.95%	Phase 2
HY-15433A	Quisinostat dihydrochloride	Inhibitor	98.28%	Phase 2
HY-16012A	Domatinostat	Inhibitor	99.43%	Phase 2
HY-16012	Domatinostat tosylate	Inhibitor	99.66%	Phase 2
HY-101780	Tinostamustine	Inhibitor	99.42%	Phase 2
HY-10223	CUDC-101	Inhibitor	99.19%	Phase 1

Pre-clinical Phase

Bioactive Molecules (25)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13428	Tubacin	Inhibitor	95.50%	Unkown
HY-15224	PCI-34051	Inhibitor	99.69%	Unkown
HY-18613	CAY10603	Inhibitor	≥98.0%	Unkown
HY-16699	Nexturastat A	Inhibitor	99.03%	Unkown
HY-115475	SW-100	Inhibitor	99.59%	Unkown
HY-111818	TH34	Inhibitor	98.41%	Unkown
HY-19747	HPOB	Inhibitor	99.80%	Unkown
HY-144779	HDAC10-IN-1	Inhibitor	99.11%	Unkown
HY-110280	MC1742	Inhibitor	99.20%	Unkown
HY-150109	Purinostat mesylate	Inhibitor	/	Unkown
HY-147731	HDAC6-IN-9	Inhibitor	/	Unkown
HY-15144B	(S)-Trichostatin A	Inhibitor	/	Unkown
HY-149283	JAK/HDAC-IN-2	Inhibitor	/	Unkown
HY-109015S	Tucidinostat-d4	Inhibitor	/	Unkown
HY-152226	MC2590	Inhibitor	/	Unkown
HY-152173	HDAC-IN-51	Inhibitor	/	Unkown
HY-144782	HDAC10-IN-2	Inhibitor	/	Unkown
HY-146684	HDAC-IN-36	Inhibitor	/	Unkown
HY-152174	HDAC-IN-52	Inhibitor	/	Unkown
HY-163430	HDAC-IN-71	Inhibitor	/	Unkown
HY-157740	XSJ-10	Inhibitor	/	Unkown
HY-19754A	CRA-026440 hydrochloride	Inhibitor	98.14%	Unkown
HY-147966	HDAC-IN-43	Inhibitor	/	Unkown
HY-150595	HDAC6-IN-10	Inhibitor	/	Unkown
HY-152225	MC2625	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HDAC10	RGD	RGD:1305874
Canis familiaris	HDAC10	VGNC	VGNC:50626
Macaca mulatta	HDAC10	VGNC	VGNC:73189
Bos taurus	HDAC10	VGNC	VGNC:49057
Mus musculus	HDAC10	MGD	MGI:2158340
Felis catus	HDAC10	VGNC	VGNC:82342

Name
Email *

	Sorry, but the email address you supplied was invalid.