HDAC10 - histone deacetylase 10 Gene

Also Known as HD10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83933

About HDAC10

Cytogenetic location: 22q13.33 Genomic coordinates (GRCh38): 22:50,245,183-50,251,265 (from NCBI)

This gene has 22 transcripts (splice variants), 181 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 10.7), bone marrow (RPKM 7.4) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

HDAC10 Products (2)

mRNA Protein Name
NM_001159286.2 NP_001152758.1 polyamine deacetylase HDAC10 isoform 2
NM_032019.6 NP_114408.3 polyamine deacetylase HDAC10 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables deacetylase activity IDA
IDA: Inferred from direct assay
28516954 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
11861901 GOA
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
11739383 GOA
enables histone deacetylase binding IDA
IDA: Inferred from direct assay
11861901 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17172643 GOA
NOT enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
28516954 GOA
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
17172643 GOA
Biological Process GO Annotation Evidence References Source
involved in homologous recombination IMP
IMP: Inferred from mutant phenotype
21247901 GOA
involved in macroautophagy IMP
IMP: Inferred from mutant phenotype
23801752 GOA
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11726666 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
11726666 GOA
involved in polyamine deacetylation IDA
IDA: Inferred from direct assay
28516954 GOA
involved in positive regulation of mismatch repair IDA
IDA: Inferred from direct assay
26221039 GOA
involved in regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
11861901 GOA
involved in spermidine deacetylation IDA
IDA: Inferred from direct assay
28516954 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
11726666 GOA
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
11861901 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
11726666 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11739383 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC10 Protein Structure

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (23 - 321)

  • 0
  • 200
  • 400
  • 600
  • 669 a.a.
Protein Preferred Names Protein Names

polyamine deacetylase HDAC10

HDAC10 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
HDAC10 Q969S8 APBB2 Homo sapiens Q92870-2
Validated Y2H
32814053
Intra
HDAC10 Q969S8 APBB2 Homo sapiens Q92870-2
Y2H Pooling
32814053
Intra
HDAC10 Q969S8 APBB2 Homo sapiens Q92870-2
Y2H Array
32814053
Intra
HDAC10 Q969S8 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
Intra
HDAC10 Q969S8 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
Intra
HDAC10 Q969S8 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
Intra
HDAC10 Q969S8 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
HDAC10 Q969S8 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
HDAC10 Q969S8 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

HDAC10 Antibodies

Cat. No. Product Name Application Reactivity
HY-P80150 HDAC10 Antibody (YA394) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Conjugate Gaze Palsy

  • Palsy Of Conjugate Gaze

  • Supranuclear Ocular Palsy

  • Gaze Palsy
Spinocerebellar Ataxia, X-Linked 5

  • SCAX5

  • X-Linked Spinocerebellar Ataxia 5

  • X-Linked Non Progressive Cerebellar Ataxia
Neuroblastoma

  • Nb

  • Neuroblastoma, Susceptibility To

  • Neuroblastomas

  • Central Neuroblastoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109015 Tucidinostat Inhibitor 98.74% Unkown
HY-14842 Givinostat Inhibitor 98.67% Yes
HY-13322 Pracinostat Inhibitor 99.80% Yes
HY-14842B Givinostat hydrochloride monohydrate Inhibitor 99.63% Yes
HY-B0494 Bufexamac Inhibitor 98.47% Unkown
HY-14842A Givinostat hydrochloride Inhibitor 98.06% Yes

Clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Phase
HY-10990 Abexinostat Inhibitor 99.00% Phase 3
HY-15433 Quisinostat Inhibitor 99.71% Phase 2
HY-13522 Fimepinostat Inhibitor 99.95% Phase 2
HY-15433A Quisinostat dihydrochloride Inhibitor 99.05% Phase 2
HY-16012A Domatinostat Inhibitor 99.34% Phase 2
HY-101780 Tinostamustine Inhibitor 99.64% Phase 2
HY-16012 Domatinostat tosylate Inhibitor 99.66% Phase 2
HY-10223 CUDC-101 Inhibitor 99.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (48)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15224 PCI-34051 Inhibitor 99.84% Unkown
HY-13428 Tubacin Inhibitor 97.11% Unkown
HY-16699 Nexturastat A Inhibitor 98.69% Unkown
HY-18613 CAY10603 Inhibitor 99.76% Unkown
HY-111818 TH34 Inhibitor 99.52% Unkown
HY-144779 HDAC10-IN-1 Inhibitor 99.87% Unkown
HY-115475 SW-100 Inhibitor 99.93% Unkown
HY-150109 Purinostat mesylate Inhibitor 99.45% Unkown
HY-19747 HPOB Inhibitor 99.54% Unkown
HY-110280 MC1742 Inhibitor 98.95% Unkown
HY-178948 HDAC10-IN-3 Inhibitor / Unkown
HY-178948A HDAC10-IN-3 formic Inhibitor 97.16% Unkown
HY-152174 HDAC-IN-52 Inhibitor 99.46% Unkown
HY-174444 PROTAC HDAC degrader-2 Degrader / Unkown
HY-19754A CRA-026440 hydrochloride Inhibitor 98.12% Unkown
HY-109015S Tucidinostat-d4 Inhibitor 98.63% Unkown
HY-157740 XSJ-10 Inhibitor 95.16% Unkown
HY-147731 HDAC6-IN-9 Inhibitor / Unkown
HY-183560 HDAC6-IN-82 Inhibitor / Unkown
HY-163803 CM-444 Inhibitor / Unkown
HY-149283 JAK/HDAC-IN-2 Inhibitor / Unkown
HY-183150 HDAC1-IN-13 Inhibitor / Unkown
HY-174471 HDAC-IN-90 Ligand / Unkown
HY-147966 HDAC-IN-43 Inhibitor / Unkown
HY-163834 HDAC6-IN-47 Inhibitor / Unkown
HY-150595 HDAC6-IN-10 Inhibitor / Unkown
HY-162658 Leuxinostat Inhibitor / Unkown
HY-179272 Wee1/HDAC-IN-1 Inhibitor / Unkown
HY-174302 PIM-1/HDAC-IN-2 Inhibitor / Unkown
HY-175030 TNI-97 Inhibitor / Unkown
HY-15433B Quisinostat hydrochloride Inhibitor / Unkown
HY-146684 HDAC-IN-36 Inhibitor / Unkown
HY-163430 HDAC-IN-71 Inhibitor / Unkown
HY-161778 ZG-126 Inhibitor / Unkown
HY-176868 Rodin-C Inhibitor / Unkown
HY-181579 HDAC6-IN-74 Inhibitor / Unkown
HY-179019 HDAC-IN-94 Inhibitor / Unkown
HY-15144B (S)-Trichostatin A Inhibitor / Unkown
HY-152226 MC2590 Inhibitor 98.71% Unkown
HY-162630 HDAC6-IN-44 Inhibitor / Unkown
HY-152225 MC2625 Inhibitor / Unkown
HY-184203 SM-06-09 Inhibitor / Unkown
HY-144782 HDAC10-IN-2 Inhibitor / Unkown
HY-181009 HDAC-IN-98 Inhibitor 98.36% Unkown
HY-174401 PROTAC HDAC6 degrader 5 Inhibitor / Unkown
HY-152173 HDAC-IN-51 Inhibitor / Unkown
HY-124946 C1A Inhibitor / Unkown
HY-19754 CRA-026440 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HDAC10 RGD RGD:1305874
Canis familiaris HDAC10 VGNC VGNC:50626
Macaca mulatta HDAC10 VGNC VGNC:73189
Bos taurus HDAC10 VGNC VGNC:49057
Mus musculus HDAC10 MGD MGI:2158340
Felis catus HDAC10 VGNC VGNC:82342
Others HDAC10 NCBI