HDAC6-IN-10
HDAC6-IN-10 is a highly selective HDAC6 inhibitor with the IC50 of 0.73 nM. HDAC6-IN-10 has 144~10941-fold selectivity over other HDAC isoforms. HDAC6-IN-10 shows anti-proliferative activities against multiple myeloma cells.
For research use only. We do not sell to patients.
- CAS No.: 2408286-73-5
- Formula: C21H20N4O4
- Molecular Weight:392.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 0.73 nM (IC50) |
HDAC10 105 nM (IC50) |
HDAC8 513 nM (IC50) |
HDAC7 752 nM (IC50) |
HDAC11 1800 nM (IC50) |
HDAC9 2560 nM (IC50) |
HDAC5 4370 nM (IC50) |
HDAC4 5620 nM (IC50) |
HDAC1 8020 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RPMI-8226 | IC50 |
33.183 μM
Compound: 21b
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Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
Antiproliferative activity against human RPMI-8226 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
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[PMID: 31865013] |
| U-266 | IC50 |
43.233 μM
Compound: 21b
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Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
Antiproliferative activity against human U-266 cells assessed as inhibition of cell growth incubated for 72 hrs by alamar blue assay
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[PMID: 31865013] |
HDAC6-IN-10 (Compound 21b) (0.1-10 μM; 24 h) treatment shows highly selective inhibition against HDAC6[1]. HDAC6-IN-10 (Compound 21b) (0-100 μM; 72 h) treatment shows anti-proliferative activities against two multiple myeloma cells RPMI-8226 and U266[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HCT-116
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Concentration:0.1, 1 and 10 μM
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Incubation Time:24 hours
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Result:Showed a dose-dependent increase in the level of Ac-tubulin.
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Cell Line:RPMI-8226 and U266 cells
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Concentration:0-100 μM
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Incubation Time:72 hours
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Result:Showed antiproliferative activities against RPMI-8226 and U266 with the IC50s of 33.183 μM and 43.233 μM, respectively.
Chemical Information
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CAS No. 2408286-73-5
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Molecular Weight 392.41
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Formula C21H20N4O4
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SMILES
O=C(NO)C1=CC=C(CN2C([C@@H](CC3=CNC4=C3C=CC=C4)NC(C2)=O)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-10 Related Classifications
HY-150595 Related Classifications
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