FGF18 - fibroblast growth factor 18 Gene

Also Known as ZFGF5; FGF-18

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8817

About FGF18

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:171,419,647-171,457,626 (from NCBI)

This gene has 1 transcript (splice variant), 224 orthologues and 21 paralogues. Biased expression in heart (RPKM 3.7), lung (RPKM 0.9) and 12 other tissues.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. It has been shown in vitro that this protein is able to induce neurite outgrowth in PC12 cells. Studies of the similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in a number of tissues, most notably the liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in regulating proliferation and differentiation of midline cerebellar structures. [provided by RefSeq, Jul 2008]

FGF18 Products (1)

mRNA Protein Name
NM_003862.3 NP_003853.1 fibroblast growth factor 18 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables type 1 fibroblast growth factor receptor binding IDA
IDA: Inferred from direct assay
16384934 GOA
enables type 2 fibroblast growth factor receptor binding IDA
IDA: Inferred from direct assay
16384934 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of MAP kinase activity IDA
IDA: Inferred from direct assay
16756958 GOA
involved in positive regulation of angiogenesis IGI
IGI: Inferred from genetic interaction
25449503 GOA
involved in positive regulation of blood vessel endothelial cell migration IGI
IGI: Inferred from genetic interaction
25449503 GOA
involved in positive regulation of endothelial cell chemotaxis to fibroblast growth factor IDA
IDA: Inferred from direct assay
16756958 GOA
NOT involved in regulation of endothelial cell proliferation IDA
IDA: Inferred from direct assay
16756958 GOA
NOT involved in regulation of sprouting angiogenesis IDA
IDA: Inferred from direct assay
16756958 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FGF18 Protein Structure

FGF

FGF: Fibroblast growth factor (53 - 175)

  • 0
  • 100
  • 207 a.a.
Protein Preferred Names Protein Names

fibroblast growth factor 18

Recombinant FGF18 Proteins

Cat. No. Product Name Accession Purity
HY-P7123 FGF-18 Protein, Human O76093 (A27-R199) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73051 FGF-18 Protein, Human (HEK293, His) O76093 (E28-A207) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700061AF Animal-Free FGF-18 Protein, Human (His) O76093 (A27-R199) ≥ 95%, as determined by reducing SDS-PAGE.

FGF18 Antibodies

Cat. No. Product Name Application Reactivity
HY-P86877 FGF18 Antibody (YA6570) WB Human, Mouse

Related Diseases

Diseases Alias
Immunodeficiency 36

  • IMD36

  • Activated Phosphoinositide 3-Kinase Delta Syndrome 2

  • Immunodeficiency, Type 36
Dyslexia
Achondroplasia, Severe, With Developmental Delay And Acanthosis Nigricans

  • SADDAN

  • Saddan Dysplasia

  • Severe Achondroplasia With Developmental Delay And Acanthosis Nigricans

  • Severe Achondroplasia-Developmental Delay-Acanthosis Nigricans Syndrome

  • Ssb Syndrome

  • Skeleton Skin Brain Syndrome

  • Skeleton-Skin-Brain Syndrome

  • Achondroplasia
Camptodactyly-Tall Stature-Scoliosis-Hearing Loss Syndrome

  • Catshl Syndrome

  • Camptodactyly-Tall Stature-Scoliosis-Deafness Syndrome
Telogen Effluvium
Hypochondroplasia

  • HCH

  • Hypochondrodysplasia

  • Chondrogenesis Imperfecta

  • Hypochondroplastic Dwarfism

  • Hypochondroplastic Short Stature
Thanatophoric Dysplasia, Type I

  • Thanatophoric Dysplasia

  • Thanatophoric Dwarfism

  • Thanatophoric Dysplasia Type 1

  • TD1

  • Td

  • Thanatophoric Short Stature

  • Thanatophoric Dwarfism Type 1

  • Thanatophoric Dysplasia Type I

  • Platyspondylic Lethal Skeletal Dysplasia, San Diego Type

  • Lethal Short-Limbed Platyspondylic Dwarfism, San Diego Type

  • Skeletal Dysplasia, San Diego Type

  • Plsd San Diego Type

  • Thanatophoric Dwarfism 1

  • Dwarfism Thanatophoric

  • Dwarf, Thanatophoric

  • Thanatophoric Dysplasia 1

  • Lethal Short-Limbed Platyspondylic Dwarfism San Diego Type

  • Platyspondylic Lethal Skeletal Dysplasia San Diego Type

  • Thanatophoric Dwarf

  • Thanatophoric Dwarfism Or Short Stature

  • Thanatophoric Dwarfism Syndrome

  • Td - [Thanatophoric Dwarfism]
Crouzon Syndrome

  • Crouzon Craniofacial Dysostosis

  • Craniofacial Dysostosis

  • Cfd1

  • Craniofacial Dysostosis Type 1

  • Crouzon Disease

  • Crouzon'S Disease

  • Craniofacial Dysostosis, Type I

  • Craniofacial Dysarthrosis

  • Craniofacial Dysostosis Syndrome

  • CS

  • Craniofacial Dysostosis Type I

  • Vogt Cephalosyndactyly
Cleft Palate, Isolated

  • Cleft Palate

  • Isolated Cleft Palate

  • CPI

  • Cp

  • Palatoschisis

  • Cleft Palate Isolated

  • Uranostaphyloschisis

  • Congenital Fissure Of Palate

  • Cleft Of Secondary Palate
Tracheomalacia

  • Congenital Tracheomalacia

  • Congenital Major Airway Collapse

  • Tracheomalacia, Congenital

  • Type 1 Tracheomalacia
Jackson-Weiss Syndrome

  • JWS

  • Craniosynostosis, Midfacial Hypoplasia, And Foot Abnormalities

  • Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities Syndrome

  • Craniosynostosis-Midfacial Hypoplasia-Foot Abnormalities
Cleidocranial Dysplasia

  • Cleidocranial Dysostosis

  • CLCD

  • Cleidocranial Dysplasia, Forme Fruste, Dental Anomalies Only

  • Cleidocranial Dysplasia, Forme Fruste, With Brachydactyly

  • CCD

  • Marie-Sainton Disease

  • Dysplasia Cleidocranial

  • Dento-Osseous Dysplasia

  • Marie-Sainton Syndrome

  • Dysplasia, Cleidocranial
Craniosynostosis

  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis
Osteochondrodysplasia

  • Skeletal Dysplasia

  • Chondrodystrophy

  • Congenital Anomaly Of Cartilage

  • Osteochondrodysplasias

  • Cartilage Development Disorder

  • Osteochondrodysplasia Syndrome

  • Dysplasia, Skeletal

  • Mucopolysaccharidosis Iv
Orofacial Cleft

  • Cleft, Orofacial
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS23652 Fgf18 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04894 FGF18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174704 Human FGF18 mRNA / Unkown
HY-RS17200 Fgf18 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FGF18 VGNC VGNC:28974
Mus musculus FGF18 MGD MGI:1277980
Macaca mulatta FGF18 VGNC VGNC:84379
Felis catus FGF18 VGNC VGNC:62250
Rattus norvegicus FGF18 RGD RGD:2608
Canis familiaris FGF18 VGNC VGNC:40845
Others FGF18 NCBI