A2A/A3 agonist-1
A2A/A3 agonist-1 is a dual A2A/A3 adenosine receptor agonist. A2A/A3 agonist-1 has a Ki value of 2.9 nM and an EC50 of 0.51 nM for hA2AAR. A2A/A3 agonist-1 has a Ki of 0.8 nM and an EC50 < 0.10 nM for hA3AR. A2A/A3 agonist-1 possesses anti-inflammatory activity and can be used for the research of inflammatory diseases.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C18H24N6O3S
- Masse moléculaire:404.49
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform Adenosine Receptor
More
Activité biologique
A2A/A3 agonist-1 (10-50 nM; 24 h) exhibits potent inhibitory effects on IL-12/IL-23p40 and IL-6 in LPS (HY-D1056)-stimulated bone marrow-derived dendritic cells (BMDCs)1.
A2A/A3 agonist-1 (1 μM; 0-60 min) shows favorable metabolic stability in human liver microsomes and plasma with no meaningful hERG inhibition1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:LPS treated BMDCs
-
Concentration:10,50 nM
-
Incubation Time:24h
-
Result:Inhibited the production of IL-12/IL-23p40 and IL-6.
Chemical Information
-
Masse moléculaire 404.49
-
Formule C18H24N6O3S
-
SMILES
O[C@H]1[C@@H](O)[C@H](N(C=N2)C3=C2C(N)=NC(C#CCCCC)=N3)S[C@@H]1C(NCC)=O
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
A2A/A3 agonist-1 Related Classifications
HY-179681 Related Classifications
Powered by Bioz