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Cat. No.: HY-162042

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AMPK activator 14

AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes.

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CAS No.: 1356632-18-2
Formule: C₃₃H₃₄FN₅O₄
Masse moléculaire:583.65

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

AMPK activator 14 Chemical Structure

CAS No.: 1356632-18-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

AMPK activator 14 (compound 32) is an orally active AMPK activator. AMPK activator 14 decreases fasted glucose and insulin levels in a db/db mouse model of Type II diabetes^[1].

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Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 32	Cytotoxicity against human A549 cells assessed as reduction in cell growth Cytotoxicity against human A549 cells assessed as reduction in cell growth	[PMID: 38079537]
HepG2	IC₅₀	1.171 μM Compound: 32	Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production Inhibition of mitochondrial function in human HepG2 cells assessed as reduction in ATP production	[PMID: 38079537]
NCI-H1299	IC₅₀	>20 μM Compound: 32	Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell growth Cytotoxicity against human NCI-H1299 cells assessed as reduction in cell growth	[PMID: 38079537]

Chemical Information

CAS No. 1356632-18-2
Masse moléculaire 583.65
Formule C₃₃H₃₄FN₅O₄
SMILES

COC1=CC=C(C=C1)C(C2CCN(CC2)C(C3=NC=C(C=C3)C(N[C@H]4CCN(CC5=CC=C(C=C5)C#N)C[C@@H]4F)=O)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Shaw SJ, et al. Optimization of Pharmacokinetic and In Vitro Safety Profile of a Series of Pyridine Diamide Indirect AMPK Activators. J Med Chem. 2023;66(24):17086-17104. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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AMPK activator 14

Voir tous les produits spécifiques à Isoform AMPK

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

AMPK activator 14 Related Classifications

HY-162042 Related Classifications