Arjungenin
Based on 1 Customer Validation
Arjungenin, a pentacyclic triterpenoid compound, is a FXR agonist. Arjungenin can improve insulin sensitivity by regulating the function of fat cells. Arjungenin exhibits moderate free radical scavenging activity. Arjungenin has growth inhibitory activity against the insect Spilarctia obliqua. Arjungenin has significant antiviral activity against a series of viruses such as chikungunya Virus (CHIKV).
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- Pureté: 98.80%
- CAS No.: 58880-25-4
- Formule: C30H48O6
- Masse moléculaire:504.70
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Stockage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
Arjungenin (100-500 μg/g diet, 72 h) exhibits FD50 (50% refusal concentration) and GI50 (50% growth inhibition concentration) of 287.1 μg/g diet and 188.5 μg/g diet against Spilarctia obliqua[1].
Arjungenin exhibits moderate free radical scavenging activity with an IC50 value of 290.6 μg/mL and exhibits inhibitory activity against the production of hypochlorous acid[2].
Arjungenin (50 μM, 8 d) significantly promotes adipogenesis in 3T3-L1 cells by activating the FXR signaling pathway, stimulates the secretion of adiponectin and leptin by adipocytes, and improves insulin sensitivity and energy metabolism[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:3T3-L1 cells
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Concentration:50 μM
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Incubation Time:8 d
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Result:Increased the secretion of adiponectin and the level of leptin.
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Cell Line:3T3-L1 cells
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Concentration:50 μM
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Incubation Time:8 d
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Result:Increased the expression of FXR, PPAR-γ, and SREBP-1c mRNA, and decreased the expression of Cyp7a1.
Chemical Information
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CAS No. 58880-25-4
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Appearance Solid
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Masse moléculaire 504.70
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Formule C30H48O6
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Color White to off-white
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SMILES
C[C@]12[C@]3(C([C@@]4([H])[C@](C(O)=O)(CCC(C)(C)[C@H]4O)CC3)=CC[C@]1([H])[C@@]5([C@@]([C@@](C)([C@@H](O)[C@H](O)C5)CO)([H])CC2)C)C
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvant et solubilité
DMSO : 50 mg/mL (99.07 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (277 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9814 mL | 9.9069 mL | 19.8138 mL | 49.5344 mL |
| 5 mM | 0.3963 mL | 1.9814 mL | 3.9628 mL | 9.9069 mL | |
| 10 mM | 0.1981 mL | 0.9907 mL | 1.9814 mL | 4.9534 mL | |
| 15 mM | 0.1321 mL | 0.6605 mL | 1.3209 mL | 3.3023 mL | |
| 20 mM | 0.0991 mL | 0.4953 mL | 0.9907 mL | 2.4767 mL | |
| 25 mM | 0.0793 mL | 0.3963 mL | 0.7926 mL | 1.9814 mL | |
| 30 mM | 0.0660 mL | 0.3302 mL | 0.6605 mL | 1.6511 mL | |
| 40 mM | 0.0495 mL | 0.2477 mL | 0.4953 mL | 1.2384 mL | |
| 50 mM | 0.0396 mL | 0.1981 mL | 0.3963 mL | 0.9907 mL | |
| 60 mM | 0.0330 mL | 0.1651 mL | 0.3302 mL | 0.8256 mL | |
| 80 mM | 0.0248 mL | 0.1238 mL | 0.2477 mL | 0.6192 mL |
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