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Cat. No.: HY-141813

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Autophagy-IN-C1

Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.

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CAS No.: 1494665-31-4
Formule: C₂₉H₂₈F₆N₄O₂
Masse moléculaire:578.55

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

Autophagy-IN-C1 Chemical Structure

CAS No.: 1494665-31-4

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Activité biologique
- Description
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Autophagy-IN-C1 not only induces apoptosis but also blocks autophagy in hepatocellular carcinoma (HCC) cells.

Cellular Effect

Cell Line	Type	Value	Description	References
HCA1	IC₅₀	0.23 μM Compound: C1	Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay Cytotoxicity against mouse HCA1 cells assessed as cell viability by MTT assay	[PMID: 34558909]
Hep 3B2	IC₅₀	0.27 μM Compound: C1	Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay Cytotoxicity against human Hep3B cells assessed as cell viability by MTT assay	[PMID: 34558909]
HepG2	IC₅₀	0.69 μM Compound: C1	Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay Cytotoxicity against human HepG2 cells assessed as cell viability by MTT assay	[PMID: 34558909]
Mahlavu	IC₅₀	0.13 μM Compound: C1	Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay Cytotoxicity against human Mahlavu cells assessed as cell viability by MTT assay	[PMID: 34558909]

Chemical Information

CAS No. 1494665-31-4
Masse moléculaire 578.55
Formule C₂₉H₂₈F₆N₄O₂
SMILES

O=C(NC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1)N[C@H]([C@@]2([H])[N@](CC3C=C)CC[C@H]3C2)C4=C(C=C(OC)C=C5)C5=NC=C4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Jin PR, et al. Cinchona Alkaloid-Inspired Urea-Containing Autophagy Inhibitor Shows Single-Agent Anticancer Efficacy. J Med Chem. 2021 Oct 14;64(19):14513-14525. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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