AZ-GHS-38
AZ-GHS-38 (compound 38) is an orally active CNS-penetrant inverse agonist of growth hormone secretagogue receptor (GHS-R1a) with an IC50 of 6.7 nM. AZ-GHS-38 results in acute reduction of food intake in wild-type mice. AZ-GHS-38 can be used for anti-obesity research.
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- CAS No.: 1143021-16-2
- Formule: C25H28ClN5O5S2
- Masse moléculaire:578.10
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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GHSR1a 6.7 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| HEK293 | IC50 |
39 nM
Compound: 38
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Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
Displacement of [125I]human ghrelin from mouse GHS-R1a expressed in HEK cell membranes after 60 mins by gamma counting method
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[PMID: 24967667] |
Chemical Information
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CAS No. 1143021-16-2
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Masse moléculaire 578.10
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Formule C25H28ClN5O5S2
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SMILES
O=C(NC1=NC2=C(S1)C=C(S(=O)(C3CCN(CC3)C)=O)C=C2)NC(C4=CC(N5CCOCC5)=CC=C4Cl)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AZ-GHS-38 Related Classifications
HY-176995 Related Classifications
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