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Cat. No.: HY-183180

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CGRP antagonist-8

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1610413-85-8
Formule: C₄₀H₄₇N₉O₅S
Masse moléculaire:765.92

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGRP antagonist-8 Chemical Structure

CAS No.: 1610413-85-8

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Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

CGRP antagonist-8 is a CGRP receptor antagonist with an IC₅₀ of 2.7 nM. CGRP antagonist-8 can be used for the research of migraine^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SK-N-MC	EC₅₀	100 nM Compound: 8	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	[PMID: 24794104]

In Vitro

CGRP antagonist-8 (Compound 8) potently inhibits CGRP receptor binding in SK-N-MC cell membrane tissue with an IC₅₀ of 2.7 nM^[1].
CGRP antagonist-8 acts as a CGRP receptor antagonist in SK-N-MC cells, with an EC₅₀ of 100 nM in the cAMP functional assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1610413-85-8
Masse moléculaire 765.92
Formule C₄₀H₄₇N₉O₅S
SMILES

O=C1N(C2CCN(CC2)C(N[C@@H](C(N[C@@H](CCCCN)C(N3CCN(C4=CC=NC=C4)CC3)=O)=O)CC5=CC6=CC=CC=C6S5)=O)C(NC7=CC=CC=C71)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Dasgupta B, et al. Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist. Bioorg Med Chem Lett. 2014;24(12):2744-2748. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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