cis-Coronaric acid
cis-Coronaric acid is the 9,10-cis epoxide of linoleic acid, generated by neutrophils during the oxidative burst. It has been recovered from the lungs of hyperoxic rats and from humans with acute respiratory distress syndrome. Mitochondrial dysfunction is the main feature of cis-Coronaric acid cytotoxicity, which may be due to the diol metabolites as well as the parent epoxide.
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- CAS No.: 61949-82-4
- Formule: C18H32O3
- Masse moléculaire:296.44
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 61949-82-4
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Masse moléculaire 296.44
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Formule C18H32O3
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SMILES
CCCCC/C=C\C[C@H]1O[C@H]1CCCCCCCC(O)=O
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Synonyms
cis-9,10-Epoxy-12(Z)-octadecenoic acid
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lahvic JL, Ammerman M, Li P, Blair MC, Stillman ER, Fast EM, Robertson AL, Christodoulou C, Perlin JR, Yang S, Chiang N, Norris PC, Daily ML, Redfield SE, Chan IT, Chatrizeh M, Chase ME, Weis O, Zhou Y, Serhan CN, Zon LI. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132. Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9252-9257. doi: 10.1073/pnas.1806077115. Epub 2018 Aug 23. PMID: 30139917; PMCID: PMC6140511. [Content Brief]
[2]. Hayakawa M, Sugiyama S, Takamura T, Yokoo K, Iwata M, Suzuki K, Taki F, Takahashi S, Ozawa T. Neutrophils biosynthesize leukotoxin, 9, 10-epoxy-12-octadecenoate. Biochem Biophys Res Commun. 1986 May 29;137(1):424-30. doi: 10.1016/0006-291x(86)91227-1. PMID: 3718512. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)