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Cat. No.: HY-119114

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E-2508 free base

E-2508 free base is an orally active and highly selective corticotropin-releasing factor type 1 receptor (CRF1) antagonist with anxiolytic effects (K_i=11 nM). E-2508 free base blocks CRF-induced cAMP accumulation via CRF1 receptor inhibition. E-2508 free base is promising for research of stress-related psychiatric disorders, such as anxiety and depression.

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CAS No.: 685885-75-0
Formule: C₂₉H₃₉N₃O₄
Masse moléculaire:493.64

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

E-2508 free base Chemical Structure

CAS No.: 685885-75-0

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

Voir tous les produits spécifiques à Isoform CRFR :

CRFR1
CRFR2

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	IC₅₀	23 nM Compound: 24r	Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluorescence analysis Antagonist activity at human CRF1 receptor expressed in HEK293 cells assessed as inhibition of CRF-stimulated cAMP accumulation after 30 mins by fluorescence analysis	[PMID: 22587443]
HEK293	IC₅₀	50 nM Compound: 24r	Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter Displacement of [125I]CRF from human CRF1 receptor expressed in HEK293 cells after 2 hrs by liquid scintillation counter	[PMID: 22587443]

Chemical Information

CAS No. 685885-75-0
Masse moléculaire 493.64
Formule C₂₉H₃₉N₃O₄
SMILES

CCC1=NN2C(C3=C(C=C(C=C3OC)COC)OC)=CC=CC2=C1N(CC4CCOCC4)CC5CC5
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Takahashi Y, et al. Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem. 2012 Jun 14;55(11):5255-69. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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E-2508 free base

Voir tous les produits spécifiques à Isoform CRFR

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

E-2508 free base Related Classifications

HY-119114 Related Classifications