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Cat. No.: HY-123677

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E2508

E2508 is an orally active corticotropin-releasing factor 1 (CRF1) receptor antagonist with a K_i value of 11 nM for hCRF1.

For research use only. We do not sell to patients.

CAS No.: 685886-34-4
Formula: C₃₆H₄₇N₃O₇S
Molecular Weight:665.84

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

E2508 Chemical Structure

CAS No.: 685886-34-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

E2508 is an orally active corticotropin-releasing factor 1 (CRF1) receptor antagonist with a K_i value of 11 nM for hCRF1^[1].

All CRFR Isoforms :

CRFR1
CRFR2

Chemical Information

CAS No. 685886-34-4
Molecular Weight 665.84
Formula C₃₆H₄₇N₃O₇S
SMILES

CCC1=NN2C(C3=C(OC)C=C(COC)C=C3OC)=CC=CC2=C1N(CC4CC4)CC5CCOCC5.O=S(C6=CC=C(C)C=C6)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Takahashi Y, et al. Synthesis and structure-activity relationships of pyrazolo[1,5-a]pyridine derivatives: potent and orally active antagonists of corticotropin-releasing factor 1 receptor. J Med Chem. 2012 Jun 14;55(11):5255-69. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
Chemical Information
Purity & Documentation
References

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E2508

All CRFR Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

E2508 Related Classifications

HY-123677 Related Classifications