E-4441
E-4441 is an orally active Antibacterial agent. E-4441 exerts broad-spectrum in vitro antibacterial activity against Gram-positive bacteria and aerobic bacteria. E-4441 exhibits protective effects against Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections. E-4441 can be used in the research of systemic bacterial infections (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa infections).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 124668-12-8
- Formule: C17H17F2N3O3
- Masse moléculaire:349.34
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
E-4441 (4 μg/mL) inhibits all anaerobic bacteria[1].
For 90% of Gram-positive bacterial isolates (Staphylococcus, Streptococcus, and Enterococcus faecalis), the minimum inhibitory concentration (MIC) of E-4441 (18 h) ranges from 0.12 to 1 μg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Escherichia coli HM-42 infection in mice, with an ED50 of 3.0 mg/kg following a single oral dose, identical to the ED50 of ciprofloxacin[1].
E-4441 (serial twofold doses; p.o.; single dose) exhibits in vivo protective activity against systemic Pseudomonas aeruginosa HS-116 infection in mice, with an ED50 of 71.7 mg/kg following a single oral dose, efficacy comparable to Ciprofloxacin[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Staphylococcus aureus HS-93)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 14.7 mg/kg.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Escherichia coli HM-42)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 3.0 mg/kg, matching the ED50 of ciprofloxacin.
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Animal Model:HC:CFLP (male, ~25 g, intraperitoneal challenge with 5× minimal lethal dose of Pseudomonas aeruginosa HS-116)[1]
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Dosage:Serial twofold doses
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Administration:p.o.; single dose
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Result:Determined an ED50 of 71.7 mg/kg, efficacy comparable to ciprofloxacin.
Chemical Information
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CAS No. 124668-12-8
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Masse moléculaire 349.34
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Formule C17H17F2N3O3
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SMILES
O=C(O)C1=CN(C2=C(F)C(=C(F)C=C2C1=O)N3CC(N)(C)C3)C4CC4
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E-4441 Related Classifications
HY-116558 Related Classifications
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