EGFR-IN-101
EGFR-IN-101 (I-10) is a 2-phenylamino pyrimidine derivative. EGFR-IN-101 is a EGFR inhibitor. The IC50 values for EGFRL858R/T790M/C797S and Ba/F3-EGFRL858R/T790M/C797S are 33.26 and 106.4 nM, respectively. EGFR-IN-101 can be used IN the study of non-small cell lung cancer (NSCLC).
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- CAS No.: 2982583-44-6
- Formule: C35H47N9O2
- Masse moléculaire:625.81
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
EGFR[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | IC50 |
106.4 nM
Compound: I-10
|
Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M/C797S mutant
Antiproliferative activity against mouse BAF3 cells harboring EGFR L858R/T790M/C797S mutant
|
[PMID: 38331226] |
Chemical Information
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CAS No. 2982583-44-6
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Masse moléculaire 625.81
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Formule C35H47N9O2
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SMILES
CN1CCN(C2CCN(C3=CC(OC)=C(NC4=NC=CC(N5C=C(CN[C@@H](C)CO)C(C6=CC=CC=C6)=N5)=N4)C=C3C)CC2)CC1
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)