FTase-IN-1
FTase-IN-1 (compound 17a) is a potent and specific inhibitor of fanesyl transferase (FTase) with an IC50 of 0.35 μM. FTase-IN-1 displays cytotoxicity potential and antitumor activity.
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- CAS No.: 2490538-41-3
- Formule: C23H16N2O2S
- Masse moléculaire:384.45
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
IC50: 0.35 μM (fanesyl transferase)[1]
FTase-IN-1 (compound 17a) (10 μM, 48 h) is an inhibitors of farnesyl transferase (FTase) and inhibits NCI-60 cells proliferation in vitro[1].
FTase-IN-1 (10 μM, 48 h) arrests the cell growth of multiple cancer cell lines with GI50 range from 1.8 to 6.5 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:NCI-H522 (lung cancer), COLO-205 and HT29 (colon cancer), SF-539 (human glioblastoma), MDA-MB-435 (melanoma), OVCAR-3 (ovarian cancer) and A498 (renal cancer)
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Concentration:10 μM
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Incubation Time:48 hours
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Result:Inhibited cell growth and showed strong antitumor activity.
Chemical Information
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CAS No. 2490538-41-3
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Masse moléculaire 384.45
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Formule C23H16N2O2S
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SMILES
CC(C1=CC(C(C2=CC=C3NC4=C(C=CC=C4)SC3=C2)=O)=C5C=CC=CN15)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
FTase-IN-1 Related Classifications
HY-149015 Related Classifications
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