Fusarochromanone
Fusarochromanone (FC-101) is a fungal metabolite with potent anti-angiogenic and anti-cancer activity. Fusarochromanone-activated JNK pathway is attributed to induction of reactive oxygen species (ROS).
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- CAS No.: 802915-53-3
- Formule: C15H20N2O4
- Masse moléculaire:292.33
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Fusarochromanone (FC101; 10 μM; 24 hours) induces apoptosis and an increase in proportion of cells in the sub-G1 phase in both HaCat and P9-WT cell lines[1].
Fusarochromanone (FC101; 0-1 μM; 24 h) induces the cleavage of both caspase-3 and PARP, a well-known substrate for activated caspases. FC101 does not affect the expression of the anti-apoptotic proteins, Bcl-2, Bcl-XL, Mcl-1, or the pro-apoptotic proteins BAD, BAK, BAX[1].
Fusarochromanone (FC101) exhibits very potent in-vitro growth inhibitory effects (IC50 ranging from 10 nM-2.5 μM) against HaCat (pre-malignant skin), P9-WT (malignant skin), MCF-7 (low malignant breast), MDA-231 (malignant breast), SV-HUC (premalignant bladder), UM-UC14 (malignant bladder), and PC3 (malignant prostate) in a time-course and dose-dependent manner, with the UM-UC14 cells being the most sensitive.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HaCat and P9-WT cell lines
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Concentration:10 μM
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Incubation Time:24 hours
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Result:Showed cells in the G2 and M phases of the cell cycle for both cell lines.
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Cell Line:MDA-MB-231 cells
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Concentration:0.05 μM, 0.1 μM, 0.2 μM, 0.5 μM, 1 μM
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Incubation Time:24 hours
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Result:Induced the cleavage of both caspase-3 and PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:SCID Beige mice (CB17/Icr.Cg-PrkdcscidLystbg/Crl) injected with SRB12-p9 cells[1]
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Dosage:8 mg/kg
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Administration:IP; 5 days per week; for 3.5 weeks
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Result:Achieved a 30% reduction in tumor size at a dose of 8 mg/kg/day.
Chemical Information
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CAS No. 802915-53-3
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Masse moléculaire 292.33
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Formule C15H20N2O4
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SMILES
O=C1CC(C)(C)OC2=CC=C(C(C[C@@H](N)CO)=O)C(N)=C12
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Synonyms
FC-101
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Structure Classification
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Initial Source
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Elahe Mahdavian, et al.Biological activities of fusarochromanone: a potent anti-cancer agent. BMC Res Notes. 2014 Sep 3;7:601. [Content Brief]
[2]. Ying Gu, et al.Fusarochromanone-induced reactive oxygen species results in activation of JNK cascade and cell death by inhibiting protein phosphatases 2A and 5. Oncotarget. 2015 Dec 8;6(39):42322-33. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fusarochromanone Related Classifications
HY-136901 Related Classifications
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