DBF4 - DBF4 zinc finger Gene

Also Known as ASK; CHIF; DBF4A; ZDBF1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10926

About DBF4

Cytogenetic location: 7q21.12 Genomic coordinates (GRCh38): 7:87,876,493-87,909,553 (from NCBI)

This gene has 8 transcripts (splice variants), 210 orthologues and 1 paralogue. Biased expression in testis (RPKM 30.3), bone marrow (RPKM 10.3) and 9 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activator activity. Predicted to be involved in positive regulation of nuclear cell cycle DNA replication and regulation of cell cycle phase transition. Located in nuclear body. [provided by Alliance of Genome Resources, Apr 2022]

DBF4 Products (4)

mRNA Protein Name
NM_001318060.2 NP_001304989.1 protein DBF4 homolog A isoform 2
NM_001318061.2 NP_001304990.1 protein DBF4 homolog A isoform 3
NM_001318062.2 NP_001304991.1 protein DBF4 homolog A isoform 4
NM_006716.4 NP_006707.1 protein DBF4 homolog A isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16899510 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DBF4 Protein Structure

zf-DBF

zf-DBF: DBF zinc finger (290 - 334)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
Protein Preferred Names Protein Names

protein DBF4 homolog A

  • DBF4 homolog

DBF4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
DBF4 Q9UBU7 HSPD1 Homo sapiens P10809
Validated Y2H
32814053
Intra
DBF4 Q9UBU7 HSPD1 Homo sapiens P10809
Y2H Array
32814053
Intra
DBF4 Q9UBU7 HSPD1 Homo sapiens P10809
Y2H Pooling
32814053
Intra
DBF4 Q9UBU7 CDC7 Homo sapiens O00311
Anti Tag CoIP
33961781
Intra
DBF4 Q9UBU7 CDC7 Homo sapiens O00311
Anti Tag CoIP
28514442
Intra
DBF4 Q9UBU7 CDC7 Homo sapiens O00311
Y2H Array
31515488
Intra
DBF4 Q9UBU7 BLMH Homo sapiens Q13867
Validated Y2H
32814053
Intra
DBF4 Q9UBU7 BLMH Homo sapiens Q13867
Y2H Array
32814053
Intra
DBF4 Q9UBU7 BLMH Homo sapiens Q13867
Y2H Pooling
32814053
Intra
DBF4 Q9UBU7 GFAP Homo sapiens P14136
Validated Y2H
32814053
Intra
DBF4 Q9UBU7 GFAP Homo sapiens P14136
Y2H Pooling
32814053
Intra
DBF4 Q9UBU7 GFAP Homo sapiens P14136
Y2H Array
32814053
Intra
DBF4 Q9UBU7 CHRNA7 Homo sapiens P36544
Validated Y2H
32814053
Intra
DBF4 Q9UBU7 CHRNA7 Homo sapiens P36544
Y2H Array
32814053
Intra
DBF4 Q9UBU7 CHRNA7 Homo sapiens P36544
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

DBF4 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82907 DBF4 Antibody (YA2652) WB Human
HY-P82907A DBF4 Antibody (YA2652)(PBS only) WB Human

Related Diseases

Diseases Alias
Meier-Gorlin Syndrome 1

  • Meier-Gorlin Syndrome

  • Ear, Patella, Short Stature Syndrome

  • Microtia, Absent Patellae, Micrognathia Syndrome

  • MGORS1

  • Eps

  • Ear-Patella-Short Stature Syndrome

  • Ear Patella Short Stature Syndrome

  • Microtia Absent Patellae Micrognathia Syndrome

  • Meier-Gorlin Syndrome, Type 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-143432 Cdc7-IN-18 Inhibitor / Unkown
HY-E70650 CDC7/DBF4 Recombinant Human Active Protein Kinase / Unkown
HY-RS03543 DBF4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18923 Dbf4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25413 Dbf4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DBF4 MGD MGI:1351328
Canis familiaris DBF4 VGNC VGNC:39780
Macaca mulatta DBF4 VGNC VGNC:71645
Rattus norvegicus DBF4 RGD RGD:1305854
Bos taurus DBF4 VGNC VGNC:27887
Felis catus DBF4 VGNC VGNC:61345
Others DBF4 NCBI