ADAMTS5 - ADAM metallopeptidase with thrombospondin type 1 motif 5 Gene

Also Known as ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11096

About ADAMTS5

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:26,917,922-26,967,088 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 25 paralogues. Broad expression in ovary (RPKM 9.8), endometrium (RPKM 9.6) and 17 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

ADAMTS5 Products (1)

mRNA	Protein	Name
NM_007038.5	NP_008969.2	A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Références	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	26668318	GOA
enables metalloendopeptidase activity	IDA IDA: Inferred from direct assay	25122765	GOA
enables metallopeptidase activity	IDA IDA: Inferred from direct assay	21370305	GOA
enables peptidase activity	IDA IDA: Inferred from direct assay	23845380	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22406378	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAMTS5 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

0
200
400
600
800
930 a.a.

Protein Preferred Names	Protein Names
A disintegrin and metalloproteinase with thrombospondin motifs 5	a disintegrin and metalloproteinase with thrombospondin motifs 11

ADAMTS5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Cross	ADAMTS5	Q9UNA0	ACAN	Bos taurus	P13608	Protease Assay	22406378

Cross: Cross-species interaction Intra: Intraspecies interaction

ADAMTS5 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P81193	ADAMTS5 Antibody (YA3480)	WB, ICC/IF, FC	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Osteoarthritis	Osteoarthrosis Degenerative Joint Disease Hypertrophic Arthritis Arthropathy Degenerative Polyarthritis Degenerative Arthritis Osteoarthrosis And Allied Disorder Arthritis, Degenerative Oa Osteoarthritis Deformans Osteoarthrosis Deformans Kashin-Beck Disease
Bone Deterioration Disease
Bone Structure Disease
Arthritis	Inflammatory Joint Disease Inflammatory Disorder Of Joint
Cartilage Disease	Cartilage Diseases Cartilage Cartilage Disorder Chondropathy Cartilage Disorders
Degenerative Disc Disease	Intervertebral Disc Degeneration Cervical Disc Degenerative Disorder Cervical Disc Degenerative Disease Lumbar Disc Degeneration Vertebral Disc Disease Degeneration Of Lumbar Intervertebral Disc Intervertebral Disc Disorder Discogenic Disease
Spondyloepimetaphyseal Dysplasia, Missouri Type	Metaphyseal Anadysplasia 1 Semd, Missouri Type Spondyloepimetaphyseal Dysplasia Type 2 SEMDM Spondyloepimetaphyseal Dysplasia Missouri Type Missouri Type Of Spondyloepimetaphyseal Dysplasia Semd Missouri Type Semd Type 2 MANDP1 Semd-Mo Spondyloepimetaphyseal Dysplasia Type Missouri Spondylometaepiphyseal Dysplasia Type Missouri Anadysplasia, Metaphyseal, Type 1
Hydrarthrosis
Spondylolisthesis	Slipped Vertebrae Acquired Spondylolisthesis
Exostosis	Osteophyte Exostoses Orbital Exostosis Exostosis Of Orbit Bone Spur Bony Outgrowth Swimmer'S Exostosis Osteophytes External Exotoses Cartilaginous Exostosis
Bone Inflammation Disease	Osteitis Bone Inflammatory Disease Inflammatory Disorder Of Bone
Weill-Marchesani Syndrome	Gemss Syndrome Spherophakia-Brachymorphia Syndrome Marchesani-Weill Syndrome Wms Congenital Mesodermal Dystrophy Mesodermal Dysmorphodystrophy, Congenital Spherophakia Brachymorphia Syndrome Mesodermal Dysmorphodystrophy Congenital Wm Syndrome Brachydactyly-Spherophakia Syndrome Brachymorphy With Spherophakia Syndrome Congenital Mesodermal Dysmorphodystrophy Marchesani Syndrome Weill-Marchesani Syndrome, Autosomal Recessive Weill-Marchesani Syndrome, Autosomal Dominant
Cardiomyopathy, Dilated, 1l	Dilated Cardiomyopathy 1l CMD1L Cardiomyopathy, Dilated 1l Cardiomyopathy, Dilated, Type 1l
Geleophysic Dysplasia	Geleophysic Dwarfism Gphysd
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta
Connective Tissue Disease	Connective Tissue Diseases Connective Tissue Disorder Abnormality Of Connective Tissue Disorder Of Connective Tissue Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-12270	T-5224	Inhibitor	99.59%	Phase 2
HY-137430	Aldumastat	Inhibitor	99.36%	Phase 2
HY-160822	AGG-523	Inhibitor	99.32%	Phase 1

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-114996	ADAMTS-5 Inhibitor	Inhibitor	99.59%	Unkown
HY-P10398	5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2 TFA		91.94%	Unkown
HY-145061	ADAMTS-5-IN-3	Inhibitor	98.89%	Unkown
HY-P5419A	WAAG-3R TFA		99.75%	Unkown
HY-135710	ADAMTS-5-IN-2	Inhibitor	98.73%	Unkown
HY-12270S	T-5224-d8		/	Unkown
HY-153505	ADAMTS-4/5-IN-1	Inhibitor	/	Unkown
HY-180781	ADAMTS-5-IN-4	Inhibitor	/	Unkown
HY-P10468	5-FAM-TEGEARGSVILLK(5-TAMRA)K-NH2		/	Unkown
HY-RS00305	ADAMTS5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18432	Adamts5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24913	Adamts5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-P992336	CRB0017	Inhibitor	/	Unkown
HY-P992358	GSK2394002	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAMTS5	RGD	RGD:735196
Mus musculus	ADAMTS5	MGD	MGI:1346321
Macaca mulatta	ADAMTS5	VGNC	VGNC:69499
Canis familiaris	ADAMTS5	VGNC	VGNC:37601
Bos taurus	ADAMTS5	VGNC	VGNC:50085
Felis catus	ADAMTS5	VGNC	VGNC:59596
Others	ADAMTS5	NCBI