ADAMTS5 - ADAM metallopeptidase with thrombospondin type 1 motif 5 Gene

Homo sapiens

Also known as ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11

Gene ID: 11096 | Gene type: protein coding

About ADAMTS5

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:26,917,922-26,967,088 (from NCBI)

This gene has 2 transcripts (splice variants), 200 orthologues and 25 paralogues. Broad expression in ovary (RPKM 9.8), endometrium (RPKM 9.6) and 17 other tissues.

Summary

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature Enzyme. This Enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]

ADAMTS5 Products(1)

mRNA	Protein	Name
NM_007038.5	NP_008969.2	A disintegrin and metalloproteinase with thrombospondin motifs 5 preproprotein

ADAMTS5 Protein Structure

Pep_M12B_propep

Reprolysin

TSP_1

ADAM_spacer1

TSP_1

0
200
400
600
800
930 a.a.

Protein Preferred Names

Protein Names

A disintegrin and metalloproteinase with thrombospondin motifs 5

a disintegrin and metalloproteinase with thrombospondin motifs 11

Related Diseases

Diseases

Alias

Osteoarthritis

Osteoarthrosis	Degenerative Joint Disease
Hypertrophic Arthritis	Arthropathy
Degenerative Polyarthritis	Degenerative Arthritis
Osteoarthrosis And Allied Disorder	Arthritis, Degenerative
Oa	Osteoarthritis Deformans
Osteoarthrosis Deformans	Kashin-Beck Disease

Bone Deterioration Disease

Bone Structure Disease

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Cartilage Disease

Cartilage Diseases	Cartilage
Cartilage Disorder	Chondropathy
Cartilage Disorders

Degenerative Disc Disease

Intervertebral Disc Degeneration	Cervical Disc Degenerative Disorder
Cervical Disc Degenerative Disease	Lumbar Disc Degeneration
Vertebral Disc Disease	Degeneration Of Lumbar Intervertebral Disc
Intervertebral Disc Disorder	Discogenic Disease

Spondyloepimetaphyseal Dysplasia, Missouri Type

Metaphyseal Anadysplasia 1	Semd, Missouri Type
Spondyloepimetaphyseal Dysplasia Type 2	SEMDM
Spondyloepimetaphyseal Dysplasia Missouri Type	Missouri Type Of Spondyloepimetaphyseal Dysplasia
Semd Missouri Type	Semd Type 2
MANDP1	Semd-Mo
Spondyloepimetaphyseal Dysplasia Type Missouri	Spondylometaepiphyseal Dysplasia Type Missouri
Anadysplasia, Metaphyseal, Type 1

Hydrarthrosis

Spondylolisthesis

Slipped Vertebrae

Acquired Spondylolisthesis

Exostosis

Osteophyte	Exostoses
Orbital Exostosis	Exostosis Of Orbit
Bone Spur	Bony Outgrowth
Swimmer'S Exostosis	Osteophytes
External Exotoses	Cartilaginous Exostosis

Bone Inflammation Disease

Osteitis	Bone Inflammatory Disease
Inflammatory Disorder Of Bone

Weill-Marchesani Syndrome

Gemss Syndrome	Spherophakia-Brachymorphia Syndrome
Marchesani-Weill Syndrome	Wms
Congenital Mesodermal Dystrophy	Mesodermal Dysmorphodystrophy, Congenital
Spherophakia Brachymorphia Syndrome	Mesodermal Dysmorphodystrophy Congenital
Wm Syndrome	Brachydactyly-Spherophakia Syndrome
Brachymorphy With Spherophakia Syndrome	Congenital Mesodermal Dysmorphodystrophy
Marchesani Syndrome	Weill-Marchesani Syndrome, Autosomal Recessive
Weill-Marchesani Syndrome, Autosomal Dominant

Cardiomyopathy, Dilated, 1l

Dilated Cardiomyopathy 1l	CMD1L
Cardiomyopathy, Dilated 1l	Cardiomyopathy, Dilated, Type 1l

Geleophysic Dysplasia

Geleophysic Dwarfism

Gphysd

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-137430	Aldumastat	Inhibitor	99.54%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12270	T-5224	Inhibitor	99.59%	Unkown
HY-114996	ADAMTS-5 Inhibitor	Inhibitor	99.30%	Unkown
HY-145061	ADAMTS-5-IN-3	Inhibitor	98.90%	Unkown
HY-135710	ADAMTS-5-IN-2	Inhibitor	98.73%	Unkown
HY-RS00305	ADAMTS5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ADAMTS5	RGD	RGD:735196
Mus musculus	ADAMTS5	MGD	MGI:1346321
Macaca mulatta	ADAMTS5	VGNC	VGNC:69499
Canis familiaris	ADAMTS5	VGNC	VGNC:37601
Bos taurus	ADAMTS5	VGNC	VGNC:50085
Felis catus	ADAMTS5	VGNC	VGNC:59596
Others	ADAMTS5	NCBI

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