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FER - FER tyrosine kinase Gene

Also Known as TYK3; PPP1R74; p94-Fer

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2241

About FER

Cytogenetic location: 5q21.3 Genomic coordinates (GRCh38): 5:108,747,897-109,196,841 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and 32 paralogues. Ubiquitous expression in thyroid (RPKM 2.8), testis (RPKM 2.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the FPS/FES family of non-transmembrane Receptor Tyrosine Kinases. It regulates cell-cell adhesion and mediates signaling from the cell surface to the Cytoskeleton via growth factor receptors. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome X. [provided by RefSeq, Apr 2015]

FER Products (4)

mRNA	Protein	Name
NM_001308028.2	NP_001294957.1	tyrosine-protein kinase Fer isoform b
NM_001308031.2	NP_001294960.1	tyrosine-protein kinase Fer isoform c
NM_001308038.2	NP_001294967.1	tyrosine-protein kinase Fer isoform d
NM_005246.4	NP_005237.2	tyrosine-protein kinase Fer isoform a

FER Protein Structure

FCH

SH2

Pkinase_Tyr

0
200
400
600
822 a.a.

Protein Preferred Names	Protein Names
tyrosine-protein kinase Fer	feline encephalitis virus-related kinase FER

FER Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Références
Intra	FER	P16591	CDC37	Homo sapiens	Q16543	Lumier	25036637
Intra	FER	P16591	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	FER	P16591	HSP90AB1	Homo sapiens	P08238	Pull Down	32707033
Cross	FER	P16591	Bcat	Gallus gallus	O42486	CoIP	15226396

Cross: Cross-species interaction Intra: Intraspecies interaction

FER Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P84133	FER Antibody (YA3830)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
HY-P84133A	FER Antibody (YA3830)(PBS only)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse
HY-P85158	FER Antibody (YA4850)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Trichothiodystrophy 5, Nonphotosensitive	TTD5 Nonphotosensitive Trichothiodystrophy 5 Trichothiodystrophy 5, Non-Photosensitive
Ceroid Lipofuscinosis, Neuronal, 6a	Neuronal Ceroid Lipofuscinosis 6 CLN6 Vlincl Cln6 Disease Ceroid Lipofuscinosis, Neuronal, 6 Late-Infantile Neuronal Ceroid Lipofuscinosis CLN6A Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant Neuronal Ceroid Lipofuscinosis 6a Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset Cln6 Disease, Adult Kufs Type A Cln6 Disease, Late Infantile Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant Ceroid Lipofuscinosis Neuronal 6 Cln6-Related Neuronal Ceroid Lipofuscinosis Late Infantile Neuronal Ceroid Lipofuscinosis Jansky-Bielschowsky Disease Lincl Late Infantile Ncl Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant Lipofuscinosis, Ceroid, Neuronal, Type 6 Ceroid Lipofuscinosis, Neuronal, 5
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Nom du produit	Effect	Pureté	Phase
HY-122844	Ifebemtinib	Inhibitor	99.86%	Phase 2
HY-10338A	Foretinib phosphate	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (18)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-100579	Ferrostatin-1	Inhibitor	99.96%	Unkown
HY-123919	TL13-112	Inhibitor	98.01%	Unkown
HY-112097	E260	Inhibitor	99.92%	Unkown
HY-122582	TL13-12	Degrader	98.16%	Unkown
HY-128576	DS21360717		99.80%	Unkown
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		99.92%	Unkown
HY-148066	DB0662	Degrader	99.66%	Unkown
HY-P10229	RALF1 peptide	Activator	98.69%	Unkown
HY-136194	TL13-22	Inhibitor	99.71%	Unkown
HY-156066	Ferrostatin-1 diyne	Inhibitor	99.9%	Unkown
HY-125142	AP-24567		/	Unkown
HY-136195	TL13-110	Inhibitor	/	Unkown
HY-161731	DS08701581	Inhibitor	/	Unkown
HY-RS04862	FER Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS04863	FER1L6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16564	Fer Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22996	Fer Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown