1. Protein Tyrosine Kinase/RTK
  2. ALK
  3. TL13-22

TL13-22 

Cat. No.: HY-136194
Handling Instructions

TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells.

For research use only. We do not sell to patients.

TL13-22 Chemical Structure

TL13-22 Chemical Structure

CAS No. : 2229036-65-9

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Description

TL13-22 is a negative control for TL13-12 (HY-122582) and a potent ALK inhibitor with an IC50 of 0.54 nM. TL13-22 does not degrade ALK in cells[1].

IC50 & Target

IC50: 0.54 nM (ALK)[1]

In Vitro

TL13-22 prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 11.3 nM, 5.74 nM, 18.4 nM, and 65.9 nM, respectively[1].

Molecular Weight

947.50

Formula

C₄₅H₅₅ClN₁₀O₉S

CAS No.

2229036-65-9

SMILES

O=C(NCCOCCOCCN1CCN(C2=CC=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C(OC)=C2)CC1)CNC5=CC=CC(C(N6C7C(NCCC7)=O)=O)=C5C6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TL13-22ALKAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246TL13-12negativecontrolAurora AFERPTK2RPS6KA1Inhibitorinhibitorinhibit

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HY-136194
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