1. Protein Tyrosine Kinase/RTK
  2. ALK
  3. TL13-110

TL13-110 

Cat. No.: HY-136195
Handling Instructions

TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells.

For research use only. We do not sell to patients.

TL13-110 Chemical Structure

TL13-110 Chemical Structure

CAS No. : 2229037-09-4

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Description

TL13-110 is a negative control for TL13-112 (HY-123919) and a potent ALK inhibitor with an IC50 of 0.34 nM. TL13-110 does not degrade ALK in cells[1].

IC50 & Target

IC50: 0.34 nM (ALK); 81 μM (Cereblon)[1]

In Vitro

TL13-110 also prompts the degradation of additional kinases including Aurora A, FER, PTK2 and RPS6KA1 with IC50 values of 9080 nM, 23.1 nM, 21.2 nM, and 480 nM, respectively.

Molecular Weight

988.59

Formula

C₄₉H₆₂ClN₉O₉S

CAS No.

2229037-09-4

SMILES

O=C(NCCOCCOCCN1CCC(C2=CC(OC(C)C)=C(NC3=NC=C(Cl)C(NC4=CC=CC=C4S(=O)(C(C)C)=O)=N3)C=C2C)CC1)CNC5=CC=CC(C(N6C7C(NCCC7)=O)=O)=C5C6=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TL13-110ALKAnaplastic lymphoma kinaseALK tyrosine kinase receptorCD246Cluster of differentiation 246negativecontrolAurora AFERPTK2RPS6KA1cereblonInhibitorinhibitorinhibit

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TL13-110
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HY-136195
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