TFF1 - trefoil factor 1 Gene

Also Known as pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7031

About TFF1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,362,282-42,366,535 (from NCBI)

This gene has 1 transcript (splice variant), 84 orthologues and 2 paralogues. Restricted expression toward stomach (RPKM 2677.9).

Summary

Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two Other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]

TFF1 Products (1)

mRNA Protein Name
NM_003225.3 NP_003216.1 trefoil factor 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TFF1 Protein Structure

Trefoil

Trefoil: Trefoil (P-type) domain (30 - 71)

  • 0
  • 84 a.a.
Protein Preferred Names Protein Names

trefoil factor 1

  • breast cancer estrogen-inducible protein

TFF1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
TFF1 P04155 ZNF250 Homo sapiens P15622-3
Validated Y2H
25416956
Intra
TFF1 P04155 ZNF250 Homo sapiens P15622-3
Y2H Prey Pooling
25416956
Intra
TFF1 P04155 PIEZO1 Homo sapiens Q92508
Anti Tag CoIP
24798994
Intra
TFF1 P04155 PIEZO1 Homo sapiens Q92508
Confocal
24798994
Intra
TFF1 P04155 PIEZO1 Homo sapiens Q92508
Y2H
24798994
Intra
TFF1 P04155 BTN3A1 Homo sapiens O00481
SPR
21982860
Intra
TFF1 P04155 BTN3A1 Homo sapiens O00481
Protein Array
21982860
Intra
TFF1 P04155 BTNL8 Homo sapiens Q6UX41
SPR
21982860
Intra
TFF1 P04155 CD300LD Homo sapiens Q6UXZ3
SPR
21982860
Intra
TFF1 P04155 FCRL4 Homo sapiens Q96PJ5
Protein Array
21982860
Intra
TFF1 P04155 FCRL4 Homo sapiens Q96PJ5
SPR
21982860
Intra
TFF1 P04155 VSNL1 Homo sapiens P62760
Validated Y2H
32296183
Intra
TFF1 P04155 UBQLN1 Homo sapiens Q9UMX0
Y2H Pooling
16189514
Intra
TFF1 P04155 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
TFF1 P04155 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TFF1 Proteins

Cat. No. Nom du produit Accession Pureté
HY-P71072 TFF1 Protein, Human (HEK293, His) P04155 (E25-F84) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71928 TFF1 Protein, Human P04155 (E25-F84) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700509 TFF1 Protein, Human (P. pastoris, N-His) P04155 (E25-F84) ≥ 90%, as determined by reducing SDS-PAGE.

TFF1 Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82632 Estrogen Inducible Protein pS2 Antibody (YA2377) WB, IHC-P, ICC/IF, IP, FC Human
HY-P85936 Estrogen Inducible Protein pS2 Antibody (YA5628) IHC-P, WB, ICC/IF, ELISA Human
HY-P86046 Estrogen Inducible Protein pS2 Antibody (YA5738) IHC-P, ELISA Human

Related Diseases

Diseases Alias
Gastric Ulcer

  • Stomach Ulcer

  • Acute Gastric Ulcer With Haemorrhage And Perforation

  • Acute Gastric Ulcer With Hemorrhage And Obstruction

  • Acute Gastric Ulcer With Hemorrhage And Perforation

  • Acute Gastric Ulcer With Hemorrhage And Perforation, With Obstruction

  • Acute Gastric Ulcer With Hemorrhage And Perforation, Without Mention Of Obstruction

  • Acute Gastric Ulcer With Hemorrhage And With Perforation But Without Obstruction

  • Acute Gastric Ulcer With Hemorrhage, With Obstruction

  • Acute Gastric Ulcer With Hemorrhage, With Perforation And With Obstruction

  • Acute Gastric Ulcer With Perforation

  • Acute Gastric Ulcer With Perforation And Obstruction

  • Acute Gastric Ulcer With Perforation, With Obstruction

  • Acute Gastric Ulcer Without Hemorrhage And Without Perforation

  • Acute Gastric Ulcer Without Hemorrhage, Without Perforation And Without Obstruction

  • Acute Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, Without Mention Of Obstruction

  • Bleeding Acute Gastric Ulcer

  • Chronic Gastric Ulcer Without Hemorrhage And Without Perforation

  • Chronic Gastric Ulcer Without Hemorrhage And Without Perforation But With Obstruction

  • Chronic Gastric Ulcer Without Mention Of Hemorrhage Or Perforation, With Obstruction

  • Gastric Ulcers

  • Cushings Ulcer

  • Cushing'S Ulcer Of Stomach

  • Peptic Ulcer Of Stomach

  • Mucosal Defect Of The Stomach
Bile Reflux
Breast Ductal Carcinoma

  • Ductal Breast Carcinoma

  • Duct Carcinoma

  • Carcinoma, Ductal

  • Mammary Ductal Carcinoma

  • Ductal Carcinoma
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Breast Disease

  • Breast Diseases
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Atrophic Gastritis

  • Gastritis, Atrophic

  • Gastric Atrophy

  • Gastritis Atrophic
Gastric Adenocarcinoma

  • Adenocarcinoma Of Stomach

  • Stomach Adenocarcinoma

  • Adenocarcinoma Gastric

  • Intestinal Type Adenocarcinoma Of Unspecified Site

  • Diffuse Type Adenocarcinoma Of Unspecified Site
Cholecystitis

  • Acute Cholecystitis

  • Chronic Cholecystitis

  • Acalculous Cholecystitis

  • Acute And Chronic Cholecystitis

  • Acute On Chronic Cholecystitis

  • Gallstone Cholecystitis

  • Cholecystitis, Acute

  • Calculus Of Gallbladder With Cholecystitis

  • Gallbladder Inflammation

  • Acute Cholecystitis Infection

  • Acute Acalculous Cholecystitis

  • Chronic Acalculous Cholecystitis

  • Nonfunctioning Gallbladder
Gastrointestinal Carcinoma

  • Gastrointestinal Neoplasms
Alcoholic Gastritis

  • Alcoholic Gastritis, With Hemorrhage

  • Alcoholic Gastritis, Without Mention Of Hemorrhage

  • Alcohol Gastritis

  • Etoh Gastritis
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Mucinous Cystadenocarcinoma

  • Cystadenocarcinoma, Mucinous

  • Pseudomucinous Cystadenocarcinoma

  • Cystadenocarcinoma Mucinous
Breast Fibroadenoma

  • Fibroadenoma

  • Fibroadenoma Of Breast

  • Juvenile Fibroadenoma Of Breast

  • Cellular Fibroadenoma

  • Complex Fibroadenoma Of Breast

  • Juvenile Fibroadenoma

  • Fibroadenoma Nos

  • Fibroadenoma Unspecified Site
Barrett Esophagus

  • Barrett'S Esophagus

  • Barrett Esophagus/Esophageal Adenocarcinoma

  • Barrett Metaplasia

  • Barrett'S Ulcer Of Esophagus

  • Ulcerative Esophagitis

  • Barrett'S Esophagus With Esophagitis

  • Barrett'S Oesophagus

  • Barretts Syndrome

  • Barrett Syndrome

  • BE

  • Peptic Ulcer Of Esophagus

  • Adenocarcinoma Of Esophagus
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Cholangiocarcinoma

  • Cholangiocarcinoma, Susceptibility To

  • Extrahepatic Cholangiocarcinoma

  • Intrahepatic Cholangiocarcinoma

  • Chlc

  • Chlc, Susceptibility To

  • Cc

  • Cholangiocarcinoma Of Biliary Tract

  • Cholangiocellular Carcinoma

  • Distal Cholangiocarcinoma

  • Perihilar Cholangiocarcinoma

  • Bile Duct Cancer

  • Cca

  • Adult Primary Cholangiocellular Carcinoma

  • Bile Duct Carcinoma
Pancreatic Cancer

  • Pancreatic Carcinoma

  • Carcinoma Of Pancreas

  • Familial Pancreatic Carcinoma

  • Pancreatic Neoplasm

  • Pancreatic Carcinoma, Familial

  • Malignant Neoplasm Of Pancreas

  • Pancreatic Acinar Carcinoma

  • Pancreatic Tumor

  • Familial Pancreatic Cancer

  • Neoplasm Of The Pancreas

  • Cancer Of The Pancreas

  • Pancreatic Carcinoma, Somatic

  • Pancreatic Cancer, Somatic

  • Ca Body Of Pancreas

  • Ca Head Of Pancreas

  • Ca Tail Of Pancreas

  • Malignant Neoplasm Of Body Of Pancreas

  • Malignant Neoplasm Of Head Of Pancreas

  • Malignant Neoplasm Of Tail Of Pancreas

  • Pancreas Neoplasm

  • Exocrine Cancer

  • Exocrine Pancreas Carcinoma

  • Hereditary Pancreatic Cancer

  • Hereditary Pancreatic Carcinoma

  • PNCA

  • Pancreatic Cancer, Susceptibility To

  • Carcinoma Of Head Of Pancreas

  • Pancreatic Neoplasms

  • Pancreatic Tumors

  • Cancer, Pancreatic

  • Cancer Of Pancreas

  • Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Endometrial Cancer

  • Endometrial Carcinoma

  • Endometrial Neoplasm

  • Malignant Neoplasm Of Endometrium

  • Endometrioid Carcinoma

  • Endometrial Neoplasms

  • Carcinoma, Endometrioid

  • Endometrial Cancer, Familial

  • Endometrial Carcinoma, Somatic

  • Endometrial Cancer, Susceptibility To

  • Endometrial Ca

  • Malignant Endometrial Neoplasm

  • Neoplasm Of Endometrium

  • Primary Malignant Neoplasm Of Endometrium

  • Tumor Of Endometrium

  • Carcinoma Of The Endometrium

  • Endometrioid Carcinoma Of Female Reproductive System

  • ENDMC

  • Carcinoma Endometrioid

  • Endometrial Cancers

  • Cancer, Endometrial

  • Uterine Corpus Cancer
Amelogenesis Imperfecta, Type Ig

  • Enamel-Renal Syndrome

  • Ers

  • Amelogenesis Imperfecta Type 1g

  • AI1G

  • Enamel-Renal-Gingival Syndrome

  • Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

  • Aigfs

  • Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

  • Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

  • Amelogenesis Imperfecta Type Ig

  • Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

  • Amelogenesis Imperfecta 1g

  • Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

  • Amelogenesis Imperfecta Nephrocalcinosis
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS14422 TFF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17752 Tff1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24219 Tff1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W106688 Triisopropyl phosphate Antagonist / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TFF1 RGD RGD:620707
Felis catus TFF1 VGNC VGNC:66119
Bos taurus TFF1 VGNC VGNC:35790
Macaca mulatta TFF1 VGNC VGNC:108446
Mus musculus TFF1 MGD MGI:88135
Canis familiaris TFF1 VGNC VGNC:47296
Others TFF1 NCBI