BTNL8 - butyrophilin like 8 Gene

Also Known as BTN9.2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79908

About BTNL8

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:180,899,159-180,950,906 (from NCBI)

This gene has 11 transcripts (splice variants), 24 orthologues and 15 paralogues. Biased expression in duodenum (RPKM 27.0), small intestine (RPKM 20.3) and 3 other tissues.

Summary

Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

BTNL8 Products (6)

mRNA Protein Name
NM_001040462.3 NP_001035552.1 butyrophilin-like protein 8 isoform 2 precursor
NM_001159707.2 NP_001153179.1 butyrophilin-like protein 8 isoform 3 precursor
NM_001159708.2 NP_001153180.1 butyrophilin-like protein 8 isoform 4 precursor
NM_001159709.2 NP_001153181.1 butyrophilin-like protein 8 isoform 5
NM_001159710.2 NP_001153182.1 butyrophilin-like protein 8 isoform 6
NM_024850.3 NP_079126.1 butyrophilin-like protein 8 isoform 1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21982860 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTNL8 Protein Structure

V-set

V-set: Immunoglobulin V-set domain (19 - 121)

PRY

PRY: SPRY-associated domain (290 - 336)

SPRY

SPRY: SPRY domain (339 - 444)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500 a.a.
Protein Preferred Names Protein Names

butyrophilin-like protein 8

  • B7-H5 costimulatory molecule

BTNL8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
BTNL8 Q6UX41 BTNL3 Homo sapiens Q6UXE8
Anti Tag CoIP
29339503
Intra
BTNL8 Q6UX41 TFF1 Homo sapiens P04155
Protein Array
21982860
Intra
BTNL8 Q6UX41 TFF1 Homo sapiens P04155
SPR
21982860
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BTNL8 Proteins

Cat. No. Product Name Accession Purity
HY-P79382 BTNL8 Protein, Human (HEK293, hFc) Q6UX41-1 (Q18-K238) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01678 BTNL8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27383 Btnl8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BTNL8 VGNC VGNC:110483
Rattus norvegicus BTNL8 RGD RGD:1587504
Others BTNL8 NCBI