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Cat. No.: HY-156202

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Geranylgeranoic acid

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Geranylgeranoic acid (Compound 5) is inhibits lysine-specific demethylase 1 (LSD1) with an IC₅₀ value of 46.97 µM. Geranylgeranoic acid induces apoptosis via loss of the mitochondrial membrane potential and activation of interleukin-1β-converting enzyme (ICE) and cysteine protease precursor 32 (CPP32) in Huh7 and PLC/PRF/5 human hepatoma cells and MLE-10 transformed mouse hepatocytes. Geranylgeranoic acid an isoprenoid with anticancer activity, which is found in S. chinensis.

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Pureté: 98.1%
CAS No.: 35750-48-2
Formule: C₂₀H₃₂O₂
Masse moléculaire:304.47

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Solution, -20°C, 2 years

Geranylgeranoic acid Chemical Structure

CAS No.: 35750-48-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

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Chemical Information

CAS No. 35750-48-2
Appearance Liquid
Masse moléculaire 304.47
Formule C₂₀H₃₂O₂
Color Colorless to light yellow
SMILES

C/C(C)=C\CC/C(C)=C/CC/C(C)=C/CC/C(C)=C/C(O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Solution, -20°C, 2 years

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (262 KB)
SDS (252 KB)
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- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Ungur N, et al. Synthetic studies on natural diterpenoid glyceryl esters[J]. Tetrahedron, 2000, 56(16): 2503-2512.

[2]. Shidoji Y, et al. Rapid loss in the mitochondrial membrane potential during geranylgeranoic acid-induced apoptosis. Biochem Biophys Res Commun. 1997 Jan 3;230(1):58-63. [Content Brief]

[3]. Sakane C, et al. Inhibition of lysine-specific demethylase 1 by the acyclic diterpenoid geranylgeranoic acid and its derivatives. Biochem Biophys Res Commun. 2014 Jan 31;444(1):24-9. [Content Brief]

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Geranylgeranoic acid

Voir tous les produits spécifiques à Isoform Histone Demethylase

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

Geranylgeranoic acid Related Classifications

HY-156202 Related Classifications