H9-KGDEVD-MMAE
H9-KGDEVD-MMAE is an antibody-drug conjugate that specifically binds to PRND to enable precise drug delivery to tumor vasculature and cancer cells. H9-KGDEVD-MMAE contains a linker cleavable by cathepsin B and caspase-3/7, allowing the release of MMAE in lysosomes. H9-KGDEVD-MMAE induces apoptosis, produces a bystander effect, and disrupts tumor vasculature. H9-KGDEVD-MMAE achieves deep tumor penetration and exhibits durable anti-tumor efficacy without systemic toxicity in preclinical models of highly vascularized malignant tumors. H9-KGDEVD-MMAE can be applied to research related to glioblastoma, sarcoma, and renal cell carcinoma.
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- CAS No.: 1932672-71-3
- Formule: C85H128N14O25
- Masse moléculaire:1746.00
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
Chemical Information
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CAS No. 1932672-71-3
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Masse moléculaire 1746.00
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Formule C85H128N14O25
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SMILES
CC(N[C@@H](CCCCNC(CCCCCN1C(C=CC1=O)=O)=O)C(NCC(N[C@@H](CC(O)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(NC2=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@@H]([C@@H](C)CC)[C@H](OC)CC(N3[C@H]([C@H](OC)[C@@H](C)C(N[C@H](C)[C@@H](O)C4=CC=CC=C4)=O)CCC3)=O)=O)=O)=O)C=C2)=O)=O)=O)=O)=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
H9-KGDEVD-MMAE Related Classifications
HY-183849 Related Classifications
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