HER2-IN-15
HER2-IN-15 (Compound 1) is an inhibitor for HER2, which inhibits the Her YVMA exon 20 insertion mutation (HER2 YVMA) with an IC50 <200 nM. HER2-IN-15 inhibits proliferation of HER2 YVMA mutated BaF3 cells with an IC50 <200 nM and amliorates non-small-cell lung cancer (NSCLC).
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- CAS No.: 3031412-82-2
- Formule: C28H29N9O2
- Masse moléculaire:523.59
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
-
Solvant et solubilité
- Pureté et documentation
- Références
-
Help & FAQs
Voir tous les produits spécifiques à Isoform EGFR
More
Activité biologique
|
Her2 exon 20 YVMA insertion <200 nM (IC50) |
Chemical Information
-
CAS No. 3031412-82-2
-
Masse moléculaire 523.59
-
Formule C28H29N9O2
-
SMILES
CC1=CC(NC2=NC=NN3C=CC(C4CN(C4)C(/C=C/CN(C)C)=O)=C23)=CC=C1OC5=CC6=NC=NN6C=C5
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvant et solubilité
DMSO : 50 mg/mL (95.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
Références
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9099 mL | 9.5495 mL | 19.0989 mL | 47.7473 mL |
| 5 mM | 0.3820 mL | 1.9099 mL | 3.8198 mL | 9.5495 mL | |
| 10 mM | 0.1910 mL | 0.9549 mL | 1.9099 mL | 4.7747 mL | |
| 15 mM | 0.1273 mL | 0.6366 mL | 1.2733 mL | 3.1832 mL | |
| 20 mM | 0.0955 mL | 0.4775 mL | 0.9549 mL | 2.3874 mL | |
| 25 mM | 0.0764 mL | 0.3820 mL | 0.7640 mL | 1.9099 mL | |
| 30 mM | 0.0637 mL | 0.3183 mL | 0.6366 mL | 1.5916 mL | |
| 40 mM | 0.0477 mL | 0.2387 mL | 0.4775 mL | 1.1937 mL | |
| 50 mM | 0.0382 mL | 0.1910 mL | 0.3820 mL | 0.9549 mL | |
| 60 mM | 0.0318 mL | 0.1592 mL | 0.3183 mL | 0.7958 mL | |
| 80 mM | 0.0239 mL | 0.1194 mL | 0.2387 mL | 0.5968 mL |
HER2-IN-15 Related Classifications
HY-163417 Related Classifications
Powered by Bioz