L-163958
L-163958 is an efficient, orally active, balanced angiotensin II receptor (AII receptor) antagonist. L-163958 has balanced high affinity for AT1 and AT2, with its IC50 values being 0.16, 0.12, 0.50, and 0.64 nM in rabbit aorta (AT1), rat midbrain (AT2), human adrenal gland (AT1), and human adrenal gland (AT2), respectively. L-163958 has a strong inhibitory effect on the pressor activity in rats. L-163958 can be used for the study of hypertension and related cardiovascular diseases.
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- CAS No.: 168473-51-6
- Formule: C33H37BrFN5O6S
- Masse moléculaire:730.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Activité biologique
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AT1 Receptor 0.16 nM (IC50) |
AT2 Receptor 0.12 nM (IC50) |
Chemical Information
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CAS No. 168473-51-6
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Masse moléculaire 730.64
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Formule C33H37BrFN5O6S
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SMILES
O=C(OC(C)(C)C)NS(=O)(C1=CC=CC=C1C2=CC=C(CN3C(CC)=NN(C4=CC(NC(CCCC)=O)=CC=C4Br)C3=O)C(F)=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
L-163958 Related Classifications
HY-114284 Related Classifications
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