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Cat. No.: HY-148147

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Metamizole

(Synonyms: Dipyrone free base; Methamizole)

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity.

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CAS No.: 50567-35-6
Formule: C₁₃H₁₇N₃O₄S
Masse moléculaire:311.36

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Metamizole Chemical Structure

CAS No.: 50567-35-6

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Activité biologique

Description

Metamizol (Methamizole) is an anti-thyroid agent, which blocks thyroid hormone production from the thyroid gland. Metamizol can cause hepatotoxicity^[1].

In Vivo

Metamizo (Methamizole; 100 mg/kg; i.p.; once; male Swiss albino mice) causes hepatotoxicity as revealed by an increase in serum alanine aminotransferase (ALT) activity^[1].
Metamizo (100 mg/kg; i.p.; once; male Swiss albino mice) causes a decrease in hepatic glutathione (GSH) contents^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Swiss albino mice (6 weeks old, 25-40 g)^[1]
Dosage:

100 mg/kg
Administration:

Intraperitoneal injection; once
Result:

Increased serum ALT level at 5 hours and the maximum serum ALT levels occurred at 5 hours.

Animal Model:

Male Swiss albino mice (6 weeks old, 25-40 g)^[1]
Dosage:

100 mg/kg
Administration:

Intraperitoneal injection; once
Result:

Induced reduction in hepatic glutathione (GSH) content in mice.

Chemical Information

CAS No. 50567-35-6
Masse moléculaire 311.36
Formule C₁₃H₁₇N₃O₄S
SMILES

O=C1C(N(CS(=O)(O)=O)C)=C(C)N(C)N1C2=CC=CC=C2
Synonyms

Dipyrone free base; Methamizole
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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Int J Biol Macromol

Reticuline isomerase AKR1B1 with aldo-keto reductase activity and detoxification function from the insect Blaps rhynchopetera. [Abstract]

2026 Mar:352:151224. PMID: 41791543
Animal Model Exp Med

Experimental study of a novel mouse model of tibial shaft fracture combined with blunt chest trauma. [Abstract]

2025 Apr;8(4):696-706. PMID: 38225728

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Heidari R, et, al. Effects of Enzyme Induction and/or Glutathione Depletion on Methimazole-Induced Hepatotoxicity in Mice and the Protective Role of N-Acetylcysteine. Adv Pharm Bull. 2014;4(1):21-8. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Metamizole

2 Cited Publications

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Metamizole

Publications Citing Use of MedChemExpress (MCE) Metamizole

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