Nocarnickelamide B
Nocarnickelamide B (Compound 2) is a linear peptide and ROCK1/2 inhibitor. Nocarnickelamide B exhibits dual inhibitory activity against ROCK1 and ROCK2 with IC50s of 14.9 μM and 21.9 μM, respectively. Nocarnickelamide B binds to the ATP-binding site. Nocarnickelamide B inhibits the activation of ROCK-regulated cytoskeletal contraction markers such as the myosin light chain. Nocarnickelamide B is potential for glaucoma reasearch.
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- Formule: C29H42N6O9
- Masse moléculaire:618.68
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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ROCK1 14.9 μM (IC50) |
ROCK2 21.9 μM (IC50) |
Chemical Information
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Masse moléculaire 618.68
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Formule C29H42N6O9
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Sequence
{DPhe}-Hyp-Gly-{DLeu}-Hyp-Gly
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Sequence Shortening
{DPhe}-Hyp-G-{DLeu}-Hyp-G
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Structure Classification
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Initial Source
Nocardiopsis sp. MCY7
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Nocarnickelamide B Related Classifications
HY-N15301 Related Classifications
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