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Cat. No.: HY-182583

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PAF antagonist-1

PAF antagonist-1 is a platelet activating factor (PAF) receptor antagonist with a target K_i of 69 nM. PAF antagonist-1 inhibits PAF binding and displays enhanced affinity at A₁, A₂^a, and A₃ adenosine receptor subtypes compared to related dihydropyridine analogs with smaller ester groups. PAF antagonist-1 can be used for cardiovascular disorders, especially hypertension and coronary heart disease.

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CAS No.: 81635-83-8
Formule: C₂₀H₂₅NO₄S
Masse moléculaire:375.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

PAF antagonist-1 Chemical Structure

CAS No.: 81635-83-8

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Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
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Activité biologique

Description

In Vitro

PAF antagonist-1 (compound 4) potently inhibits PAF receptor binding with a K_i of 69 nM^[1].
PAF antagonist-1 shows no activity at rat brain membrane L-type calcium channels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 81635-83-8
Masse moléculaire 375.48
Formule C₂₀H₂₅NO₄S
SMILES

O=C(C1=C(C)NC(C)=C(C1C)C(OCCSC2=CC=CC=C2)=O)OCC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. van Rhee AM, et al. Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. J Med Chem. 1996;39(15):2980-2989. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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