PF-06663195
PF-06663195 is a β-secretase (BACE1) inhibitor, with BACE1 CFA and BACE1 WCA IC50 values of 53 and 15 nM, respectively. PF-06663195 can be used for Alzheimer's disease research.
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- CAS No.: 1621585-22-5
- Formule: C18H18F3N3O2S
- Masse moléculaire:397.41
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
10.1 μM
Compound: 13
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Inhibition of human ERG expressed in CHO cells
Inhibition of human ERG expressed in CHO cells
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[PMID: 25781223] |
| H4 | IC50 |
53 nM
Compound: 13
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Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay
Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assay
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[PMID: 25781223] |
Chemical Information
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CAS No. 1621585-22-5
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Masse moléculaire 397.41
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Formule C18H18F3N3O2S
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SMILES
FC[C@@H]1[C@@]2([H])[C@](N=C(S1)N)(C3=C(C=C(C=C3)F)F)CO[C@@H](C4=CC(C)=NO4)C2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PF-06663195 Related Classifications
HY-138013 Related Classifications
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