PLK4-IN-7
PLK4-IN-7 is a selective and orally active PLK4 inhibitor with an IC50 value of 7.9 nM. PLK4-IN-7 exhibits potent antitumor activity and favorable metabolic stability. PLK4-IN-7 can be used for the research of tumors such as neuroblastoma.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C20H19F6N7O2
- Masse moléculaire:503.40
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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PLK4 7.9 nM (IC50) |
PLK4-IN-7 (Compound 25) (5 days) can inhibit the viability of CHP-134 neuroblastoma cells, with an EC50 value of 88 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:CHP-134 neuroblastoma tumor-bearing mouse xenograft model[1]
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Dosage:30 mg/kg, 100 mg/kg
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Administration:p.o., twice daily for 16 days
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Result:Was well-tolerated with no significant body weight loss observed during the treatment period, and the final tumor growth inhibition rates were 115% (30 mg/kg group) and 117% (100 mg/kg group), respectively.
Chemical Information
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Masse moléculaire 503.40
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Formule C20H19F6N7O2
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SMILES
O=C(NC1=CNN=C1C2=CC3=C(C=N2)C=NN3CC(F)(F)F)N4C5(C[C@@](C(F)(F)F)(CC4)O)CC5
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLK4-IN-7 Related Classifications
HY-180111 Related Classifications
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