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Cat. No.: HY-117055

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Ro 18-3981

Ro 18-3981 is a dihydropyridine that inhibits cardiac Ca²⁺ channels. Ro 18-3981 shows higher inhibitory activity when the cell membrane is in a depolarized state (V_h=-20 mV: IC₅₀=2.3 nM; V_h=-50 mV: IC₅₀=100 nM).

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CAS No.: 103295-92-7
Formule: C₂₄H₃₃N₃O₈S
Masse moléculaire:523.60

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Data Sheet (266 KB)

Ro 18-3981 Chemical Structure

CAS No.: 103295-92-7

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Chemical Information

CAS No. 103295-92-7
Masse moléculaire 523.60
Formule C₂₄H₃₃N₃O₈S
SMILES

O=C(C1=C(C)NC(C)=C(C(CS(=O)(NC(C)C)=O)=O)C1C2=CC=CC([N+]([O-])=O)=C2)OCCOCCC
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Holck M, et al. Inhibition of myocardial Ca2+ channels by three dihydropyridines with different structural features: potential‐dependent blockade by Ro 18–3981[J]. British journal of pharmacology, 1987, 91(1): 61-67. [Content Brief]

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Ro 18-3981

Voir tous les produits spécifiques à Isoform Calcium Channel

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Chemical Information

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Références

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Ro 18-3981 Related Classifications

HY-117055 Related Classifications