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Cat. No.: HY-19436A

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Solabegron hydrochloride

(Synonyms: GW 427353B)

1 Cited Publications

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Solabegron hydrochloride is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome.

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CAS No.: 451470-34-1
Formule: C₂₃H₂₄Cl₂N₂O₃
Masse moléculaire:447.35

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Data Sheet (265 KB)

Solabegron hydrochloride Chemical Structure

CAS No.: 451470-34-1

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Description

Solabegron hydrochloride is a selective β₃-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β₃-AR, with an EC₅₀ value of 22 nM^[1]. Solabegron hydrochloride (GW 427353) is being developed for the treatment of overactive bladder and irritable bowel syndrome^[1].

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Chemical Information

CAS No. 451470-34-1
Masse moléculaire 447.35
Formule C₂₃H₂₄Cl₂N₂O₃
SMILES

O=C(C1=CC(C2=CC=CC(NCCNC[C@@H](C3=CC=CC(Cl)=C3)O)=C2)=CC=C1)O.[H]Cl
Synonyms

GW 427353B
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Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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PLoS One

Vibegron shows high selectivity and potent agonist activity for β3-adrenoceptors, irrespective of receptor density. [Abstract]

2023 Sep 1;18(9):e0290685. PMID: 37656760

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (265 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Hicks A, et al. GW427353 (solabegron), a novel, selective beta3-adrenergic receptor agonist, evokes bladder relaxation and increases micturition reflex threshold in the dog. J Pharmacol Exp Ther. 2007 Oct;323(1):202-9. [Content Brief]

[2]. Andersson KE, et al. Selective β3-adrenoceptor agonists for the treatment of overactive bladder. J Urol. 2013 Oct;190(4):1173-80. [Content Brief]

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Solabegron hydrochloride

1 Cited Publications

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Solabegron hydrochloride

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Voir tous les produits spécifiques à Isoform Adrenergic Receptor

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Publications (1)

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Solabegron hydrochloride Related Classifications

HY-19436A Related Classifications