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Cat. No.: HY-185356

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SR-14968

SR-14968 is a full, allosteric and non-competitive MOR agonist, with an EC₅₀ of 88 nM for MOR in mouse brainstem. SR-14968 stabilizes MOR in a G protein signaling state that is resistant to washout but reversible by antagonists. SR-14968 induces respiratory depression in mice. SR-14968 can be used in pain-related research.

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CAS No.: 2133455-40-8
Formule: C₂₀H₂₀BrCl₂N₃O
Masse moléculaire:469.20

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Please store the product under the recommended conditions in the Certificate of Analysis.

SR-14968 Chemical Structure

CAS No.: 2133455-40-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
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- IC₅₀ & Target
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- In Vivo
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Description

IC₅₀ & Target^[1]

μ Opioid Receptor/MOR

88 nM (EC₅₀)

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In Vitro

SR-14968 acts as a full agonist of MOR in the mouse brainstem, with an EC₅₀ of 88 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SR-14968 (10 mg/kg; i.p.) induces respiratory depression in male C57BL/6J mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2133455-40-8
Masse moléculaire 469.20
Formule C₂₀H₂₀BrCl₂N₃O
SMILES

BrC(C=C1)=CC=C1C(C)N2CCC(N(C3=CC(Cl)=C(C=C3N4)Cl)C4=O)CC2
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Stahl EL, et al. G protein signaling-biased mu opioid receptor agonists that produce sustained G protein activation are noncompetitive agonists. Proc Natl Acad Sci U S A. 2021;118(48):e2102178118. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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SR-14968

Voir tous les produits spécifiques à Isoform Opioid Receptor

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

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SR-14968 Related Classifications

HY-185356 Related Classifications