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Telisotuzumab

(Synonyms: ABT-700; ABBV-400 Antibody)
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Telisotuzumab (ABT-700) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab induces apoptosis. Telisotuzumab can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers.

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  • Pureté: 99.91%
  • CAS No.: 1781223-80-0
  • Masse moléculaire:146.1 kDa
  • Stockage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for Telisotuzumab
  • Experimental Validation Results for Telisotuzumab
  • Experimental Validation Results for Telisotuzumab
  • Telisotuzumab Chemical Structure
    Telisotuzumab Chemical Structure
CAS No.: 1781223-80-0
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609-228-6898
[email protected] [email protected]
Trouvez votre distributeur local Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    Human IgG1 kappa

  • 1/16

    Flow cytometry analysis of cMet overexpression CHOK1 cells labelling cMet with Telisotuzumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).

  • 1/16

    Immobilized HGFR Protein, Human (His) can bind Telisotuzumab. The EC50 for this effect is 65.95 ng/mL.

  • Telisotuzumab Chemical Structure
    1/16
  • Telisotuzumab
  • Flow cytometry analysis of cMet overexpression CHOK1 cells labelling cMet with Telisotuzumab at 20 nM (Red). Goat anti human IgG Fc (Alexa Fluor488) was used as the secondary antibody at 1/1000 dilution. Isotype control - human IgG (Blue). Unlabeled control - Unlabelled cells (Gray).
  • Immobilized HGFR Protein, Human (His) can bind Telisotuzumab. The EC50 for this effect is 65.95 ng/mL.