Tetracosactide acetate
Based on 1 Customer Validation
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC50 of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis.
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- Pureté: 99.35%
- CAS No.: 60189-34-6
- Formule: C136H210N40O31S.xC2H4O2
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Stockage:
Sealed storage, away from moisture and light, under nitrogen.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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MC4R 0.65 nM (EC50) |
Tetracosactide (11 nM, 3-60 h) promotes the protein synthesis in rats/mice adrenal slices, promotes the secretion of cortisol, 11-deoxycorticosterone, and aldosterone[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Rabbits spinal cord IR injury models[2]
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Dosage:0.5 mg/kg
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Administration:iv, single dose
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Result:Reduced MDA, XO, MPO, caspase-3 in tissue and serum, inproved the levels of CAT.
Chemical Information
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CAS No. 60189-34-6
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Appearance Solid
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Formule C136H210N40O31S.xC2H4O2
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Color White to off-white
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Synonyms
Tetracosactrin acetate; ACTH(1–24) acetate
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Sequence Shortening
SYSMEHFRWGKPVGKKRRPVKVYP
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Sealed storage, away from moisture and light, under nitrogen
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Solvant et solubilité
H2O : ≥ 100 mg/mL
* "≥" means soluble, but saturation unknown.
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: ≥ 50 mg/mL; Clear solution
Pureté et documentation
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Fiche technique (271 KB)
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SDS (557 KB)
- English - EN (557 KB)
- Français - FR (557 KB)
- Deutsch - DE (557 KB)
- Norwegian - NO (557 KB)
- Español - ES (557 KB)
- Swedish - SV (557 KB)
- Italian - IT (557 KB)
- Korean - KR (557 KB)
- Portuguese - PT (557 KB)
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Instruction de manipulation (2659 KB)
Références
[2]. Kertmen H, et al., Comparative effects of methylprednisolone and tetracosactide (ACTH1-24) on ischemia/reperfusion injury of the rabbit spinal cord. Arch Med Sci. 2018 Oct;14(6):1459-1470. [Content Brief]
[3]. Haslach EM, et al., Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs). J Med Chem. 2014 Jun 12;57(11):4615-28. [Content Brief]
[4]. Lindhe O, et al., Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue-slice culture. Environ Health Perspect. 2001 Feb;109(2):105-10. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tetracosactide acetate Related Classifications
HY-P0060A Related Classifications
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