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Cat. No.: HY-184560

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VL285-PEG3-I

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405).

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CAS No.: 2254609-31-7
Formule: C₃₅H₄₃IN₄O₇S
Masse moléculaire:790.71

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

VL285-PEG3-I Chemical Structure

CAS No.: 2254609-31-7

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- Description
- In Vitro
Chemical Information
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Description

VL285-PEG3-I (Compound 6) is an E3 ligase ligand-linker conjugate. VL285-PEG3-I is used for the synthesis of PROTAC SJFδ (HY-114405)^[1].

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates :

In Vitro

E3 ligase ligand-linker conjugates are components of proteolysis-targeting chimeras (PROTACs). They consist of a ligand for an E3 ubiquitin ligase and a linker, and when connected to a ligand for a target protein (e.g., JQ1 binds to BRD4, Molibresib binds to BET proteins), they can be used to construct PROTACs that induce ubiquitination and degradation of the target protein.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2254609-31-7
Masse moléculaire 790.71
Formule C₃₅H₄₃IN₄O₇S
SMILES

ICCOCCOCCOC1=CC(C2=C(C)N=CS2)=CC=C1CNC([C@@H]3C[C@@H](O)CN3C([C@@H](N4C(C5=CC=CC=C5C4)=O)C(C)C)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Smith BE, et al.. Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase. Nature communications. 2019 Jan 10;10(1):131. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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VL285-PEG3-I

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

VL285-PEG3-I Related Classifications

HY-184560 Related Classifications