115 Results for "

calcitonin

" in MedChemExpress (MCE) Product Catalog:
Products (115)

115 Results for "calcitonin" in MCE Product Catalog:

45
45 Publications Verification
Cat. No.: HY-10095
CAS No.: 204697-65-4
Purity:  99.83%
Synonyms: BIBN-4096; BIBN 4096BS
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Olcegepant (BIBN-4096) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and Ki of 14.4 pM for human CGRP .
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45
45 Publications Verification
Cat. No.: HY-10095A
CAS No.: 586368-06-1
Purity:  99.11%
Synonyms: BIBN-4096 hydrochloride; BIBN4096BS hydrochloride
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Olcegepant hydrochloride (BIBN-4096 hydrochloride) is a potent and selective non-peptide antagonist of the calcitonin gene-related peptide 1 (CGRP1) receptor with IC50 of 0.03 nM and with a Ki of 14.4 pM for human CGRP .
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12
12 Cited Publications
Cat. No.: HY-15498A
CAS No.: 1374024-48-2
Synonyms: BMS-927711 sulfate hydrate; BHV-3000 sulfate hydrate
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Rimegepant (BMS-927711) sulfate hydrate is a potent, orally active, selective and competitive calcitonin gene-related peptide (CGRP) receptor antagonist with a Ki of 0.027 nM and an IC50 of 0.14 nM for hCGRP receptor. Rimegepant sulfate hydrate can be used for migraine research .
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9
9 Cited Publications
Cat. No.: HY-P0203
CAS No.: 83651-90-5
Synonyms: CGRP (83-119), mouse, rat
α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies .
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9
9 Cited Publications
Cat. No.: HY-P0203A
Synonyms: CGRP (83-119), mouse, rat TFA
α-CGRP (mouse, rat) TFA, a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) TFA can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) TFA has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies .
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6
6 Cited Publications
Cat. No.: HY-P1071
CAS No.: 90954-53-3
Synonyms: calcitonin gene-related peptide
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

α-CGRP (human) (Calcitonin gene-related peptide) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) is widely distributed in the central and peripheral nervous system. α-CGRP (human) is a potent vasodilator and has inotropic and chronotropic effects .
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6
6 Cited Publications
Cat. No.: HY-P1071A
Synonyms: calcitonin gene-related peptide TFA
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

α-CGRP (human) (TFA) is a regulatory neuropeptide of 37 amino acids. α-CGRP (human) (TFA) is widely distributed in the central and peripheral nervous system. α-CGRP (human) (TFA) is a potent vasodilator and has inotropic and chronotropic effects .
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4
4 Cited Publications
Cat. No.: HY-P1471
CAS No.: 159899-65-7
Synonyms: 22-52-Adrenomedullin (human)
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

Adrenomedullin (AM) (22-52), human, an NH2 terminal truncated adrenomedullin analogue, is an adrenomedullin receptor antagonist, and also antagonizes the calcitonin generelated peptide (CGRP) receptor in the hindlimb vascular bed of the cat .
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3
3 Cited Publications
Cat. No.: HY-P0090
CAS No.: 47931-85-1
Synonyms: Salmon calcitonin
Target:  

CGRP Receptor

Research Areas:  

Cancer

Calcitonin salmon, a calcium regulating hormone, is a dual-action amylin and calcitonin receptor agonist, could stimulate bone formation and inhibit bone resorption.
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3
3 Cited Publications
Cat. No.: HY-P3462
CAS No.: 1415456-99-3
Target:  

CGRP Receptor

Research Areas:  

Metabolic Disease

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
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3
3 Cited Publications
Cat. No.: HY-P77587
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: calcitonin; CCP; PDN-21; CALCA; CALC1; CGRP; CGRP-I; CGRP1; CT; KC; PCT; Procalcitonin; calcitonin 1; Katacalcin
Species:  
Source:  
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2
2 Cited Publications
Cat. No.: HY-32709
CAS No.: 781649-09-0
Synonyms: MK-0974
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Telcagepant (MK-0974) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist with Kis of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively.
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2
2 Cited Publications
Cat. No.: HY-P99019
CAS No.: 1655501-53-3
Synonyms: TEV-48125; LBR-101; PF-04427429; RN-307
Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC50 values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC50 value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine .
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2
2 Cited Publications
Cat. No.: HY-P1014
CAS No.: 119911-68-1
Synonyms: Human α-CGRP (8-37)
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

HCGRP-(8-37) (Human α-CGRP (8-37)) is a fragment of human calcitonin gene-related peptide (hCGRP) and an antagonist of the CGRP receptor, with an IC50 of 32.1 pM against the CGRP receptor. HCGRP-(8-37) blocks adenylate cyclase activation induced by CGRP receptor ligands and attenuates vascular responses triggered by CGRP. HCGRP-(8-37) reduces capsaicin-induced vasodilation in porcine nasal mucosa and superficial skin. HCGRP-(8-37) serves as a research tool to distinguish effects mediated by CGRP or calcitonin receptors, and to investigate CGRP-induced vascular effects .
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1
1 Cited Publications
Cat. No.: HY-Y1892
CAS No.: 121548-04-7
Gelucire 44/14 is a potential and safe absorption enhancer for improving the absorption of poorly absorbable agents including insulin and calcitonin by pulmonary delivery.
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1
1 Cited Publications
Cat. No.: HY-P1548
CAS No.: 101462-82-2
Synonyms: Human β-CGRP; CGRP-II (Human)
β-CGRP, human (Human β-CGRP) is one of calcitonin peptides, acts via the complex of calcitonin-receptor-like receptor (CRLR) and receptor-activity-modifying protein (RAMP), with IC50s of 1 nM and 300 nM for CRLR/RAMP1 and CRLR/RAMP2 in cells .
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1
1 Cited Publications
Cat. No.: HY-134992
CAS No.: 1337918-83-8
Purity:  99.54%
Synonyms: Zavegepant; BHV-3500
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Vazegepant (Zavegepant) is an orally active calcitonin gene-related peptide (CGRP) receptor antagonist. Vazegepant can be used in the study of migraine .
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1
1 Cited Publications
Cat. No.: HY-P9938
CAS No.: 1582205-90-0
Synonyms: AMG-334

Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Erenumab (AMG-334) is a fully human monoclonal antibody. Erenumab inhibits the calcitonin gene-related peptide (CGRP) receptor. Erenumab prevents the increase in dermal blood flow in cynomolgus monkeys. Erenumab can be used in the research of episodic migraine .
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1
1 Cited Publications
Cat. No.: HY-P4058
CAS No.: 83652-28-2
Synonyms: CGRP free acid
Target:  

CGRP Receptor

Research Areas:  

Neurological Disease

Calcitonin gene-related peptide (CGRP) free acid is a 37-amino acid neuropeptide, which represents the deamidated form of α-CGRP (human) (HY-P1071). Calcitonin gene-related peptide free acid is produced in the central and peripheral nervous systems of rats, and localizes to specific sensory, integrative and motor neuron systems, including those involved in nociception/thermoreception, feeding behavior, olfaction and visceral motor functions .
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1
1 Cited Publications
Cat. No.: HY-P1913A
Synonyms: CGRP II (rat) TFA
Target:  

CGRP Receptor

Research Areas:  

Cardiovascular Disease

Calcitonin Gene Related Peptide II rat TFA, a CGRP receptor activator, is a potent and long-lasting vasodilator. Calcitonin Gene Related Peptide II rat TFA can be used in the research of cardiovascular diseases .
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